asat.Rd
\name{asat}
\alias{asat}
\docType{data}
\title{ Toxicological Study on Female Wistar Rats }
\description{
ASAT-values for a new compound and a control group of 34 female Wistar
rats.
}
\usage{data("asat")}
\format{
A data frame with 34 observations on the following 2 variables.
\describe{
\item{asat}{the ASAT-values (a liver enzyme)}
\item{group}{a factor with levels \code{Compound} and \code{Control}.}
}
}
\details{
The aim of this toxicological study is the proof of safety for the new
compound. The data are originally given in Hothorn (1992) and reproduced in
Hauschke et al. (1999).
}
\source{
Ludwig A. Hothorn (1992), Biometrische Analyse toxikologischer Untersuchungen.
In: J. Adams (ed.): \emph{Statistisches Know how in der medizinischen
Forschung.} Ullstein-Mosby, Berlin, 475--590.
}
\references{
Dieter Hauschke, Meinhard Kieser & Ludwig A. Hothorn (1999),
Proof of safety in
toxicology based on the ratio of two means for normally distributed data.
\emph{Biometrical Journal} \bold{41}(3), 295--304.
Rafael Pfl{\"u}ger & Torsten Hothorn (2002),
Assessing Equivalence Tests with Respect to their Expected
$p$-Value. \emph{Biometrical Journal} \bold{44}(8), 1002--1027.
}
\examples{
data("asat", package = "coin")
### proof-of-safety based on ratio of medians
pos <- wilcox_test(I(log(asat)) ~ group, data = asat, alternative = "less",
conf.int = TRUE, distribution = "exact")
### one-sided confidence set. Safety cannot be concluded since the effect of
### the compound exceeds 20\% of the control median
exp(confint(pos)$conf.int)
}
\keyword{datasets}