# GENETIC UNCOUPLING OF STRUCTURE AND FUNCTION IN HUMAN TRANSMODAL CORTEX > Data and code to think about structure-function associations
> From "Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex", Valk et al., preprint
> https://www.biorxiv.org/content/10.1101/2021.06.08.447522v1
--- ## Table of Contents - [Dependencies](#step-by-step) - [Step by step guide to analysis approach](#step-by-step) - [Manuscript data](#manuscript-data) - [Support](#support) --- ### Dependencies - For the current work, we rely on brainspace (download here: https://brainspace.readthedocs.io/en/latest/pages/install.html), surfstat: https://mica-mni.github.io/surfstat/, scientific colourmaps: https://www.fabiocrameri.ch/colourmaps/, raincloudplots: https://github.com/RainCloudPlots/RainCloudPlots; abagen https://abagen.readthedocs.io/en/stable/ and NeuroSynth https://www.neurosynth.org, MPC code: https://github.com/MICA-MNI/micaopen/tree/master/MPC - For the analyses we use surfaces constructed from freesurfer (fsaverage 5) and Schaefer 400 (7 networks) parcel solution. ### Step by step Check out structure and function using the following steps.
1. First we correlated the rows of the structural and functional matrices. 2. We did the same for the mean functional/structural matrix with their heritability maps - as well as heritability of structure-function coupling, and for macaques. 3. To compare humans and macaque data on the surface, we used Ting Xu's code and approach: https://github.com/CNG-LAB/PRIME-DE 4. To evaluate the topology we used brainspace to construct gradients. 5. For decoding we combined maps from step 1 and 4 in a 2D framework and mapped cytoarchitecture/functional communities, as well as phylogenetic models (dual origin and functional reorganisation between macaques and humans), transcriptomic data (AHBA, using abagen) and functional terms (NeuroSynth). ### Manuscript data - Main data is from HCP and PRIME-DE which is openly available. - Auxiliary data is in a .mat file. Do let me know if you think something is missing. --- ### Support Feel free to get in touch if you have any questions (valk@cbs.mpg.de)