https://github.com/cran/mratios
Tip revision: 9e9b168e0ae9f6496427dfddc8d10685833267d1 authored by Frank Schaarschmidt on 03 April 2008, 00:00:00 UTC
version 1.3.11
version 1.3.11
Tip revision: 9e9b168
Mutagenicity.Rd
\name{Mutagenicity}
\alias{Mutagenicity}
\docType{data}
\title{ Mutagenicity assay }
\description{
Mutagenicity assay for 4 doses of a compound (hydroquinone) against a negative (vehicle) control and a positive (active) control (cyclophosphamide).
Hydroquinone was applied in doses of 30, 50, 70, 100 mg/kg, positive control was applied with 25mg/kg.
Counts of micronuclei in polychromatic erythrocytes after 24h are taken as a measure for the potency to induce chromosome damage. Data of male mice are presented
(Hauschke et al., 2005).
}
\usage{data(Mutagenicity)}
\format{
A data frame with 31 observations on the following 2 variables.
\describe{
\item{Treatment}{a factor with levels Cyclo25, Hydro100, Hydro30, Hydro50, Hydro75, Vehicle}
\item{MN}{a numeric vector, giving the counts of micronuclei after 24h}
}
}
\source{
\emph{Adler, ID, and Kliesch, U (1990).}
Comparison of single and multiple treatment regiments in the mouse bone marrow micronucleus assay for hydroquinone and cyclophosphamide.
\emph{Mutation Research 234, 115-123.}
}
\references{
\emph{Hauschke, D, Slacik-Erben, R, Hansen, S, Kaufmann,R (2005).}
Biostatistical Assessment of mutagenicity studies by including the positive control.
\emph{Biometrical Journal 47, 82-87.}
}
\examples{
data(Mutagenicity)
str(Mutagenicity)
boxplot(MN~Treatment, data=Mutagenicity)
}
\keyword{datasets}