https://github.com/DIDEO/DIDEO
Tip revision: 0437eb02f48ca48866ebe7f3211f68da6a6b5786 authored by Mathias Brochhausen on 25 October 2023, 14:08:00 UTC
Merge pull request #21 from cthoyt/patch-1
Merge pull request #21 from cthoyt/patch-1
Tip revision: 0437eb0
dideo.owl
<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/dideo.owl/"
xml:base="http://purl.obolibrary.org/obo/dideo.owl/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:efo="http://www.ebi.ac.uk/efo/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:terms="http://purl.org/dc/terms/"
xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:apollo_sv="http://purl.obolibrary.org/obo/apollo_sv.owl/"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
<owl:Ontology rdf:about="http://purl.obolibrary.org/obo/dideo.owl">
<owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/dideo/release/2023-10-16/dideo.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/bfo/2014-05-03/classes-only.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/iao/2017-03-24/iao.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/ro/core.owl"/>
<obo:IAO_0000118 xml:lang="en">Drug-drug Interaction and Drug-drug Interaction Evidence Ontology</obo:IAO_0000118>
<dc:contributor xml:lang="en">Anuj Shah</dc:contributor>
<dc:contributor xml:lang="en">Dan Malone</dc:contributor>
<dc:contributor xml:lang="en">Jessica Tay-Sontheimer</dc:contributor>
<dc:contributor xml:lang="en">Jingjing Yu</dc:contributor>
<dc:contributor xml:lang="en">Jodi Schneider</dc:contributor>
<dc:contributor xml:lang="en">Philip E. Empey</dc:contributor>
<dc:contributor xml:lang="en">Richard D. Boyce</dc:contributor>
<dc:contributor xml:lang="en">William R. Hogan</dc:contributor>
<dc:creator xml:lang="en">Mathias Brochhausen</dc:creator>
<terms:license xml:lang="en">http://creativecommons.org/licenses/by/4.0/</terms:license>
<rdfs:comment xml:lang="en">The Drug-drug Interaction and Drug-drug Interaction Evidence Ontology (DIDEO) by the DIDEO development group is licensed under CC BY 4.0
(https://creativecommons.org/licenses/by/4.0/).</rdfs:comment>
<rdfs:comment xml:lang="en">The Drug-drug Interaction and Drug-drug Interaction Evidence Ontology (DIDEO) by the DIDEO development group is licensed under CC BY 4.0. You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. You must give appropriate credit (by using the original ontology IRI for the whole ontology and original term IRIs for individual terms), provide a link to the license, and
indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</rdfs:comment>
<rdfs:label xml:lang="en">DIDEO</rdfs:label>
<owl:versionInfo xml:lang="en">2023-10-16</owl:versionInfo>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/BFO_0000179 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000179">
<rdfs:label xml:lang="en">BFO OWL specification label</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000180 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000180">
<rdfs:label xml:lang="en">BFO CLIF specification label</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/CLO_0000178 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/CLO_0000178">
<rdfs:label>Cell line LINCS ID</rdfs:label>
<rdfs:label xml:lang="en">Cell line LINCS ID</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/CLO_0037192 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/CLO_0037192">
<rdfs:label xml:lang="en">STR profile</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/IAO_0000111 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000111">
<rdfs:label>editor preferred label</rdfs:label>
<rdfs:label xml:lang="en">editor preferred label</rdfs:label>
<rdfs:label>editor preferred term</rdfs:label>
<rdfs:label xml:lang="en">editor preferred term</rdfs:label>
<rdfs:label>editor preferred term~editor preferred label</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000112 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000112">
<rdfs:label xml:lang="en">example of usage</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000114 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000114">
<rdfs:label>has curation status</rdfs:label>
<rdfs:label xml:lang="en">has curation status</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
<rdfs:label>definition</rdfs:label>
<rdfs:label xml:lang="en">definition</rdfs:label>
<rdfs:label>textual definition</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000116 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000116">
<rdfs:label xml:lang="en">editor note</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">editor note</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000117 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000117">
<rdfs:label>definition editor</rdfs:label>
<rdfs:label xml:lang="en">definition editor</rdfs:label>
<rdfs:label>term editor</rdfs:label>
<rdfs:label xml:lang="en">term editor</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000118 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000118">
<rdfs:label>alternative term</rdfs:label>
<rdfs:label xml:lang="en">alternative term</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000119 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000119">
<rdfs:label>definition source</rdfs:label>
<rdfs:label xml:lang="en">definition source</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000231 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000231"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000232 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000232">
<rdfs:label>curator note</rdfs:label>
<rdfs:label xml:lang="en">curator note</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/IAO_0000412 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000412">
<rdfs:label xml:lang="en">imported from</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000424 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000424">
<rdfs:label xml:lang="en">expand expression to</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000589 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000589">
<rdfs:label xml:lang="en">OBO foundry unique label</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/IAO_0000600 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000600">
<rdfs:label>elucidation</rdfs:label>
<rdfs:label xml:lang="en">elucidation</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/IAO_0000602 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000602">
<rdfs:label xml:lang="en">has associated axiom(fol)</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/INO_0000006 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/INO_0000006">
<rdfs:label xml:lang="en">has literature mining keywords</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/MPIO_0000001 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/MPIO_0000001">
<rdfs:label xml:lang="en">MPIO user-centered definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/OBI_0001847 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001847">
<rdfs:label xml:lang="en">ISA alternative term</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/OBI_9991118 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/OBI_9991118">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB alternative term</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/RO_0001900 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0001900">
<rdfs:label xml:lang="en">temporal interpretation</rdfs:label>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/RO_0002575 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002575">
<rdfs:label>is direct form of</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002579 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002579">
<rdfs:label>is indirect form of</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/UBPROP_0000001 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000001">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">external_definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/UBPROP_0000007 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000007">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_relational_adjective</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/hasAlternativeId -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/hasAlternativeId"/>
<!-- http://purl.obolibrary.org/obo/hasDbXref -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/hasDbXref"/>
<!-- http://purl.obolibrary.org/obo/hasExactSynonym -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/hasExactSynonym"/>
<!-- http://purl.obolibrary.org/obo/hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/hasOBONamespace"/>
<!-- http://purl.obolibrary.org/obo/hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/hasRelatedSynonym"/>
<!-- http://purl.obolibrary.org/obo/apollo_sv.owl/APOLLO_SV_0000040 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/apollo_sv.owl/APOLLO_SV_0000040">
<rdfs:label xml:lang="en">Unique Apollo Label</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/ncbitaxon#has_rank -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/ncbitaxon#has_rank">
<rdfs:label>has_rank</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.org/dc/elements/1.1/creator -->
<rdf:Description rdf:about="http://purl.org/dc/elements/1.1/creator">
<rdfs:label xml:lang="en-us">Creator</rdfs:label>
</rdf:Description>
<!-- http://purl.org/dc/elements/1.1/source -->
<rdf:Description rdf:about="http://purl.org/dc/elements/1.1/source">
<rdfs:label>Source</rdfs:label>
<rdfs:label xml:lang="en-us">Source</rdfs:label>
</rdf:Description>
<!-- http://www.ebi.ac.uk/efo/AAO_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/AAO_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/ArrayExpress_label -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/ArrayExpress_label"/>
<!-- http://www.ebi.ac.uk/efo/BILA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/BILA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/BTO_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/BTO_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/CALOHA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/CALOHA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/EFO_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/EFO_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/EV_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/EV_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/FBbt_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/FBbt_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/FMA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/FMA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/GAID_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/GAID_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/MAT_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/MAT_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/MA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/MA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/MESH_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/MESH_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/MIAA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/MIAA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/NCI_Thesaurus_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/NCI_Thesaurus_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/SNOMEDCT_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/SNOMEDCT_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/TADS_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/TADS_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/TAO_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/TAO_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/WBbt_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/WBbt_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/Wikipedia_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/Wikipedia_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/XAO_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/XAO_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/ZFA_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/ZFA_definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/alternative_term -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/alternative_term">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alternative_term</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.ebi.ac.uk/efo/definition -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/definition">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.ebi.ac.uk/efo/definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/definition_citation"/>
<!-- http://www.ebi.ac.uk/efo/definition_editor -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/definition_editor"/>
<!-- http://www.ebi.ac.uk/efo/galen_definition_citation -->
<owl:AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/galen_definition_citation"/>
<!-- http://www.geneontology.org/formats/oboInOwl#created_by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasAlternativeId -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_alternative_id</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_broad_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">database_cross_reference</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasDefinition -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDefinition"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_exact_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_narrow_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace">
<rdfs:label>has_obo_namespace</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_related_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#id -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
<!-- http://www.geneontology.org/formats/oboInOwl#inSubset -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in_subset</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.w3.org/2000/01/rdf-schema#label -->
<rdf:Description rdf:about="http://www.w3.org/2000/01/rdf-schema#label">
<rdfs:label>label</rdfs:label>
</rdf:Description>
<!-- http://www.w3.org/2000/01/rdf-schema#seeAlso -->
<rdf:Description rdf:about="http://www.w3.org/2000/01/rdf-schema#seeAlso">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">see also</rdfs:label>
</rdf:Description>
<!-- http://xmlns.com/foaf/0.1/page -->
<owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/page"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/BFO_0000050 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">is part of</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">my brain is part of my body (continuant parthood, two material entities)</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this day is part of this year (occurrent parthood)</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">a core relation that holds between a part and its whole</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.</obo:IAO_0000116>
<obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
<obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)
A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">part_of</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
<rdfs:label xml:lang="en">part of</rdfs:label>
<rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections"/>
<rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:PartOf"/>
<rdfs:seeAlso>http://www.obofoundry.org/ro/#OBO_REL:part_of</rdfs:seeAlso>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000051 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000051">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">has part</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">my body has part my brain (continuant parthood, two material entities)</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this year has part this day (occurrent parthood)</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">a core relation that holds between a whole and its part</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.</obo:IAO_0000116>
<obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
<obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)
A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">has_part</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
<rdfs:label xml:lang="en">has part</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000062 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000062">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002086"/>
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">preceded by</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">is preceded by</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">preceded_by</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/obi.owl)</obo:IAO_0000412>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<dc:source>http://www.obofoundry.org/ro/#OBO_REL:preceded_by</dc:source>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">preceded by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000063 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000063">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<obo:IAO_0000111 xml:lang="en">precedes</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">precedes</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000068 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000068">
<obo:IAO_0000115 xml:lang="en">continuant(c) and process(p) and first_time_point(p,t1) and last_time_point(p,t2) and not(exists_at(c,t1)) and exists_at(c,t2)</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
<dc:source xml:lang="en">https://code.google.com/p/bfo/issues/detail?id=50&colspec=ID%20Type%20Status%20Owner%20Summary%20Reporter%20Modified</dc:source>
<rdfs:label xml:lang="en">begins_to_exist_during</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000117 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000117">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:BFO_0000179>o-has-part</obo:BFO_0000179>
<obo:BFO_0000180>hasOccurrentPart</obo:BFO_0000180>
<obo:IAO_0000112>[copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life</obo:IAO_0000112>
<obo:IAO_0000112>[copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football.</obo:IAO_0000112>
<obo:IAO_0000112>[copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match.</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])</obo:IAO_0000115>
<obo:IAO_0000116>[copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.</obo:IAO_0000116>
<obo:IAO_0000116>[copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent</obo:IAO_0000116>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/bfo.owl</obo:IAO_0000412>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dideo/release/2017-11-17/dideo.owl</obo:IAO_0000412>
<obo:IAO_0000600>[copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002])</obo:IAO_0000600>
<obo:IAO_0000602>(iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001] </obo:IAO_0000602>
<rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
<rdfs:label xml:lang="en">has occurrent part</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000027 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000027">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000068"/>
<obo:IAO_0000115 xml:lang="en">there is some extended organism e
& there is some temporal region tr
& p occupies temporal region tr
& p occurs_in e
& c begins to exist during p
& there is some t
( t part-of tr & c located-in e at t )</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<rdfs:label xml:lang="en">organismally_begins_to_exist_during</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000028 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000028">
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000029"/>
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000115 xml:lang="en">there is some extended organism e
& p1 occurs_in e
& p2 occurs_in e
& p1 immediately precedes p2</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<dc:source xml:lang="en">for immediatly precedes please see: http://krr.meraka.org.za/~aow2010/Trentelman-etal.pdf</dc:source>
<rdfs:label xml:lang="en">organismally immediately precedes</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000029 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000029">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<rdfs:label xml:lang="en">is organismally immediately preceded by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000041 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000041">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
<rdfs:domain>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
</rdfs:domain>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000427"/>
<obo:IAO_0000115 xml:lang="en">A pharmaeutic ingredient or a metabolite X is the substrate of an enzyme E, iff E catalyzes X to M.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">is substrate of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000085 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000085">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/IDO_0100872"/>
<obo:IAO_0000231 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000103"/>
<rdfs:label xml:lang="en">realizes substrate role</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000086 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000086">
<obo:IAO_0000231 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000103"/>
<rdfs:label xml:lang="en">involves substrate</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000090 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000090">
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002449"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000096"/>
</owl:propertyChainAxiom>
<rdfs:label xml:lang="en">inhibits-catalyzes metabolism of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000096 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000096">
<rdfs:label xml:lang="en">catalyzes a Phase I or Phase II enzymatic reaction involving</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/IAO_0000136 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000136"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000142 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000142"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000293 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000293"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000295 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000295">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<obo:IAO_0000111 xml:lang="en">is_specified_input_of</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">is_specified_input_of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/OBI_0000312 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000312">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<obo:IAO_0000111 xml:lang="en">is_specified_output_of</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">is_specified_output_of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/OBI_0001927 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001927">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<obo:IAO_0000111>specifies value of</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115>A relation between a value specification and an entity which the specification is about.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/obi.owl)</obo:IAO_0000412>
<rdfs:label>specifies value of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/OBI_0001938 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001938">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<obo:IAO_0000111>has value specification</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115>A relation between an information content entity and a value specification that specifies its value.</obo:IAO_0000115>
<obo:IAO_0000117>PERSON: James A. Overton</obo:IAO_0000117>
<obo:IAO_0000119>OBI</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label>has value specification</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/OBI_1110060 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_1110060">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">process is result of</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The production of IFN-gamma by effector T cells is a process result of T cell stimulation through the TCR</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is a relationship between a process and a preceding occurrent that directly caused the later one to occur</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/obi.owl)</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">process is result of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0000052 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000052">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">inheres in</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">this fragility inheres in this vase</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this red color inheres in this apple</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">A dependent inheres in its bearer at all times for which the dependent exists.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">inheres_in</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
<rdfs:label xml:lang="en">inheres in</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0000053 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000053"/>
<!-- http://purl.obolibrary.org/obo/RO_0000056 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000056">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">participates in</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">this blood clot participates in this blood coagulation</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this input material (or this output material) participates in this process</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this investigator participates in this investigation</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">a relation between a continuant and a process, in which the continuant is somehow involved in the process</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">participates_in</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">participates in</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0000057 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000057">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000111 xml:lang="en">has participant</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">this blood coagulation has participant this blood clot</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this investigation has participant this investigator</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">this process has participant this input material (or this output material)</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">a relation between a process and a continuant, in which the continuant is somehow involved in the process</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">has_participant</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<dc:source>http://www.obofoundry.org/ro/#OBO_REL:has_participant</dc:source>
<rdfs:label xml:lang="en">has participant</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002086 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002086">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
<obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:comment xml:lang="en">X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)</rdfs:comment>
<rdfs:label xml:lang="en">ends after</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002087 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002087">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
<obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
<obo:IAO_0000118>starts_at_end_of</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/obi.owl)</obo:IAO_0000412>
<rdfs:comment xml:lang="en">X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
<rdfs:label xml:lang="en">immediately preceded by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002090 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002090">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002224"/>
</owl:propertyChainAxiom>
<obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
<obo:IAO_0000118>ends_at_start_of</obo:IAO_0000118>
<obo:IAO_0000118>meets</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:comment xml:lang="en">X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
<rdfs:label xml:lang="en">immediately precedes</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002211 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002211">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
</owl:propertyChainAxiom>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
</owl:propertyChainAxiom>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x regulates y if and only if the x is the realization of a function to exert an effect on the frequency, rate or extent of y</obo:IAO_0000115>
<obo:IAO_0000116>We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000117>David Hill</obo:IAO_0000117>
<obo:IAO_0000117>Tanya Berardini</obo:IAO_0000117>
<obo:IAO_0000119>GO</obo:IAO_0000119>
<obo:IAO_0000232>Regulation does not preclude parthood; the regulatory process may be upstream, or may be within the regulated process.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000589>regulates (processual)</obo:IAO_0000589>
<obo:IAO_0000600 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000600>
<rdfs:label xml:lang="en">regulates</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002212 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002212">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
</owl:propertyChainAxiom>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x negatively regulates y if and only if the progression of x reduces the frequency, rate or extent of y</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000589>negatively regulates (process to process)</obo:IAO_0000589>
<rdfs:label xml:lang="en">negatively regulates</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002214 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002214">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000112>'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))</obo:IAO_0000112>
<obo:IAO_0000112>heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation.</obo:IAO_0000115>
<obo:IAO_0000116>Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)</obo:IAO_0000116>
<obo:IAO_0000116>This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants.</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">has prototype</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002215 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000112>mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)</obo:IAO_0000112>
<obo:IAO_0000112>osteoclast SubClassOf 'capable of' some 'bone resorption'</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>has function realized in</obo:IAO_0000118>
<obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20123131"/>
<obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21208450"/>
<obo:IAO_0000232>For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000424>RO_0000053 some (RO_0000054 only ?Y)</obo:IAO_0000424>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">capable of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002216 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002216">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
</owl:propertyChainAxiom>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>has function in</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000424>RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))</obo:IAO_0000424>
<rdfs:label xml:lang="en">capable of part of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002217 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002217">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x actively participates in y if and only if x participates in y and x realizes some active role</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>agent in</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">actively participates in</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002222 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002222">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000119 rdf:resource="https://en.wikipedia.org/wiki/Allen%27s_interval_algebra"/>
<obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<dc:source rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1</dc:source>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:comment>A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.</rdfs:comment>
<rdfs:label xml:lang="en">temporally related to</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002224 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002224">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000112>Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>started by</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">starts with</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002230 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002230">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115>x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>finished by</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">ends with</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002233 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002233">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
<obo:IAO_0000115 xml:lang="en">p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">consumes</obo:IAO_0000118>
<rdfs:label xml:lang="en">has input</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002234 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002234">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002353"/>
<obo:IAO_0000115 xml:lang="en">p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">produces</obo:IAO_0000118>
<rdfs:label xml:lang="en">has output</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002327 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002327">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
<obo:IAO_0000112>a particular instances of akt-2 enables some instance of protein kinase activity</obo:IAO_0000112>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>catalyzes</obo:IAO_0000118>
<obo:IAO_0000118>executes</obo:IAO_0000118>
<obo:IAO_0000118>has</obo:IAO_0000118>
<obo:IAO_0000232>This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">enables</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002328 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002328">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000232>This is a grouping relation that collects relations used for the purpose of connecting structure and function</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">functionally related to</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002333 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002333">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
<obo:IAO_0000115>inverse of enables</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">enabled by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002334 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002334">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
<obo:IAO_0000115>inverse of regulates</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000589>regulated by (processual)</obo:IAO_0000589>
<rdfs:label xml:lang="en">regulated by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002335 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002335">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">negatively regulated by</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002352 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002352">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<obo:IAO_0000115>inverse of has input</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/ro.owl)</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">input of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002353 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002353">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<obo:IAO_0000115>inverse of has output</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Optional.of(http://purl.obolibrary.org/obo/ro.owl)</obo:IAO_0000412>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label xml:lang="en">output of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002404 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002404">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000115>inverse of upstream of</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">causally downstream of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002408 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002408">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>directly negatively regulates</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000589>directly inhibits (process to process)</obo:IAO_0000589>
<rdfs:label xml:lang="en">directly inhibits</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002409 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002409">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>indirectly negatively regulates</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:RO_0002579 rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
<rdfs:label xml:lang="en">indirectly inhibits</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002410 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002410">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002609"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000115>This relation groups causal relations between material entities and causal relations between processes</obo:IAO_0000115>
<obo:IAO_0000116>This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.
To define causal relations in an activity-flow type network, we make use of 3 primitives:
* Temporal: how do the intervals of the two occurrents relate?
* Is the causal relation regulatory?
* Is the influence positive or negative
The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.
For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.
For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.
Each of these 3 primitives can be composed to yield a cross-product of different relation types.</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">causally related to</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002411 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002411">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000115>p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">causally upstream of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002412 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002412">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002090"/>
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
<obo:IAO_0000115>p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
<rdfs:label xml:lang="en">immediately causally upstream of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002418 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002418">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
<obo:IAO_0000115>p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.</obo:IAO_0000115>
<obo:IAO_0000116>We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>influences (processual)</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causally upstream of or within</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002427 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002427">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causally downstream of or within</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002434 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002434">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000115>A relationship that holds between two entities in which the processes executed by the two entities are causally connected.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">Considering relabeling as 'pairwise interacts with'</obo:IAO_0000116>
<obo:IAO_0000116>This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000232>Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym>in pairwise interaction with</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
<rdfs:label>interacts with</rdfs:label>
<rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0914</rdfs:seeAlso>
<foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://code.google.com/p/obo-relations/wiki/InteractionRelations</foaf:page>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002436 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002436">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002434"/>
<obo:IAO_0000115>An interaction relationship in which the two partners are molecular entities and are executing molecular processes that are directly causally connected.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>binds</obo:IAO_0000118>
<obo:IAO_0000118>molecularly binds with</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>molecularly interacts with</rdfs:label>
<rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ECO_0000353"/>
<rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0915</rdfs:seeAlso>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002448 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002448">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002436"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
</owl:propertyChainAxiom>
<obo:IAO_0000115>Holds between molecular entities a and b when the execution of a activates or inhibits the activity of b</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>molecularly controls</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002449 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002449">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002408"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
</owl:propertyChainAxiom>
<obo:IAO_0000115>Holds between molecules a and b if and only if a executes a process that directly diminishes a process executed by b.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000118>inhibits</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>molecularly decreases activity of</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002500 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002500">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
<obo:IAO_0000115>A relationship between a material entity and a process where the material entity has some causal role that influences the process</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causal agent in</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002501 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002501">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
<obo:IAO_0000115>p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
<obo:IAO_0000119>https://docs.google.com/document/d/1WxocTXZaGVhEV1n7NB86pCF3SUcBJh8bq4vQrVCkjSU/edit#</obo:IAO_0000119>
<obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causal relation between processes</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002506 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002506">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000116>The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causal relation between material entities</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002566 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002566">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
<owl:propertyChainAxiom rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
</owl:propertyChainAxiom>
<obo:IAO_0000115>Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b</obo:IAO_0000115>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<obo:IAO_0000589>causally influences (material entity to material entity)</obo:IAO_0000589>
<rdfs:label>causally influences</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002595 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002595">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000115>A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.</obo:IAO_0000115>
<obo:IAO_0000116>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000116>
<obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>causal relation between material entity and a process</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/RO_0002609 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002609">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000115>A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.</obo:IAO_0000115>
<obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ro.owl</obo:IAO_0000412>
<rdfs:label>related via dependence to</rdfs:label>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#has_proper_part -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#has_proper_part">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<owl:inverseOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#proper_part_of"/>
<obo:IAO_0000232 xml:lang="en">DIDEO uses this object property from the old (depracted) RO, since we need to infer parts of drug products as represented by DRON (and DRON [along with many other OBO Foundry candidate ontologies] uses this object property).</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ido.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId>OBO_REL:0000007</oboInOwl:hasAlternativeId>
<oboInOwl:hasOBONamespace>relationship</oboInOwl:hasOBONamespace>
<rdfs:label xml:lang="en">has_proper_part</rdfs:label>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#proper_part_of -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#proper_part_of">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<obo:IAO_0000232 xml:lang="en">DIDEO uses this object property from the old (depracted) RO, since we need to infer parts of drug products as represented by DRON (and DRON [along with many other OBO Foundry candidate ontologies] uses this object property).</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ido.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId>OBO_REL:0000006</oboInOwl:hasAlternativeId>
<oboInOwl:hasDefinition>
<rdf:Description/>
</oboInOwl:hasDefinition>
<oboInOwl:hasOBONamespace>relationship</oboInOwl:hasOBONamespace>
<rdfs:label xml:lang="en">proper_part_of</rdfs:label>
</owl:ObjectProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Data properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/OBI_0001937 -->
<owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001937">
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
<rdfs:range rdf:resource="http://www.w3.org/2002/07/owl#real"/>
<obo:IAO_0000111 xml:lang="en">has specified value</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115>A relation between a value specification and a number that quantifies it.</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">A range of 'real' might be better than 'float'. For now we follow 'has measurement value' until we can consider technical issues with SPARQL queries and reasoning.</obo:IAO_0000116>
<obo:IAO_0000117 xml:lang="en">PERSON: James A. Overton</obo:IAO_0000117>
<obo:IAO_0000119>OBI</obo:IAO_0000119>
<rdfs:label xml:lang="en">has specified value</rdfs:label>
</owl:DatatypeProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/APOLLO_SV_00000032 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/APOLLO_SV_00000032">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
<obo:IAO_0000115 xml:lang="en">A measurement datum that is the output of counting.</obo:IAO_0000115>
<obo:IAO_0000117>Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/apollo_sv/dev/apollo_sv.owl</obo:IAO_0000412>
<obo:IAO_0000600 xml:lang="en">A measurement datum that is the output of counting.</obo:IAO_0000600>
<apollo_sv:APOLLO_SV_0000040 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">count</apollo_sv:APOLLO_SV_0000040>
<rdfs:label xml:lang="en">count</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/APOLLO_SV_00000461 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/APOLLO_SV_00000461">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0020000"/>
<obo:IAO_0000115 xml:lang="en">An identifier that denotes a drug product.</obo:IAO_0000115>
<obo:IAO_0000117>Matthew Diller</obo:IAO_0000117>
<obo:IAO_0000117>William R. Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/apollo_sv/v4.1.1./apollo_sv.owl</obo:IAO_0000412>
<obo:IAO_0000600 xml:lang="en">An identifier that denotes a drug product.</obo:IAO_0000600>
<apollo_sv:APOLLO_SV_0000040 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">drugId</apollo_sv:APOLLO_SV_0000040>
<rdfs:label xml:lang="en">drug identifier</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/BFO_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000001"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000027 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000027"/>
<!-- http://purl.obolibrary.org/obo/CHEBI_101278 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_101278">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_82814"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4602</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:3573079</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:42399-41-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11937779</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:16651034</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:19167257</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23687551</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24261918</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:25122162</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:8369596</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00343</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB14487</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:42399-41-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C06958</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D07845</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NIST Chemistry WebBook:42399-41-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:DE1805714</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:DE3415035</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US3562257</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US4552695</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:3573079</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Diltiazem</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DILTIAZEM</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diltiazem</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C22H26N2O4S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-cis-diltiazem</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">d-cis-diltiazem</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diltiazem</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diltiazemum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:101278</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diltiazem</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_13389 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_13389">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abbreviation for nicotinamide-adenine dinucleotide when its oxidation state is unknown or unspecified. It is used in metabolic pathways like glycolysis and citric acid cycle.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB00902</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Nicotinamide_adenine_dinucleotide</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NAD</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nicotinamide-adenine dinucleotide</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13389</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NAD</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_15822 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15822">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A steroid glucosiduronic acid having 17alpha-estradiol as the steroid component.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:14218</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23962</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4863</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C04300</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17alpha-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17alpha-estradiol 3-glucuronide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">448.210</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">448.50610</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C24H32O8</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Estradiol-17alpha 3-D-glucuronoside</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17-,18+,19+,20-,21+,23-,24+/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MUOHJTRCBBDUOW-FNUZHIFDSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc1cc(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)ccc21</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:15822</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17alpha-estradiol 3-glucosiduronic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_15986 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15986">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33695"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13672</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:14859</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:8312</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C00419</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Polynucleotide</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C10H17O10PR2(C5H8O6PR)n</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polynucleotides</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:15986</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polynucleotide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_16474 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16474">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13399</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13400</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:21904</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:44286</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:7425</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:77911</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:53-57-6</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:MOL000028</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ECMDB:ECMDB04111</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB00221</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C00005</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00019545</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:NDP</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16884311</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17371809</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:8627598</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">YMDB:YMDB00426</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">745.091</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">745.42116</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ACFIXJIJDZMPPO-NNYOXOHSSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C21H30N7O17P3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reduced nicotinamide adenine dinucleotide phosphate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TPNH</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dihydronicotinamide-adenine dinucleotide phosphate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">reduced nicotinamide-adenine dinucleotide phosphate</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:16474</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_16856 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16856">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:12402</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:14327</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:24334</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:42873</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:43049</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:5437</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:70-18-8</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00143</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:1312</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB00125</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C00051</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00014</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00001518</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MetaCyc:GLUTATHIONE</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:GSH</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17439666</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:4200890</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:4745654</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:1729812</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Glutathione</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutathione</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">L-gamma-glutamyl-L-cysteinylglycine</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">307.084</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">307.32300</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-L-Glutamyl-L-cysteinylglycine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C10H17N3O6S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GSH</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutathione-SH</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RWSXRVCMGQZWBV-WDSKDSINSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reduced glutathione</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gamma-L-Glutamyl-L-cysteinyl-glycine</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:16856</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutathione</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_16908 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16908">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_13389"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13395</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13396</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:21902</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:44216</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:7423</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:79324</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:58-68-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:MOL000027</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00157</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gmelin:544241</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB01487</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C00004</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00019343</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:NAI</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11259315</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19459318</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:79324</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Nicotinamide_adenine_dinucleotide</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADH</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">665.125</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">665.44126</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BOPGDPNILDQYTO-NNYOXOHSSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C21H29N7O14P2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DPNH</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reduced nicotinamide adenine dinucleotide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nicotinamide adenine dinucleotide (reduced)</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:16908</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADH</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_17200 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17200">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A UDP-sugar having alpha-D-glucuronic acid as the sugar component.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13489</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13506</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:22104</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:46309</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:9846</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:78881</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:2616-64-0</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB00935</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C00167</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:G10612</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00007238</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:UGA</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11420884</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:13984680</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:14351193</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:78881</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Uridine_diphosphate_glucuronic_acid</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uridine 5'-[3-(alpha-D-glucopyranuronosyl) dihydrogen diphosphate]</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">580.034</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">580.28538</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C15H22N2O18P2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HDYANYHVCAPMJV-LXQIFKJMSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UDP-D-glucuronate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UDP-alpha-D-glucuronate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UDP-glucuronate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UDPglucuronate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uridine diphosphate glucuronic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:17200</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UDP-alpha-D-glucuronic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_17980 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17980">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35701"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An adenosine bisphosphate having monophosphate groups at the 3'- and 5'-positions and a sulfo group attached to the phosphate at position 5'.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:11679</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:11680</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:1353</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:19857</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:482-67-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C00053</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00007446</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:PPS</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-O-phosphono-5'-adenylyl sulfate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-Phospho-5'-adenylyl sulfate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-phospho-5'-adenylyl sulfate</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-Phosphoadenosine 5'-phosphosulfate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-Phosphoadenylyl sulfate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-phosphoadenosine 5'-phosphosulfate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">506.986</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">507.26552</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C10H15N5O13P2S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GACDQMDRPRGCTN-KQYNXXCUSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PAPS</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:17980</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3'-phospho-5'-adenylyl sulfate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_18946 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_18946">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25000"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A lactone having a six-membered lactone ring.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-lactone</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1,5-lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1,5-lactones</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-lactona</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-lactonas</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-lactones</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:18946</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-lactone</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_22715 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22715">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27171"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organic heterocyclic compound containing a benzene ring fused to an imidazole ring.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:22715</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">benzimidazoles</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_23367 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23367">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">entidad molecular</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">entidades moleculares</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">entite moleculaire</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molekulare Entitaet</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23367</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_23677 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23677">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_68452"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diazoles</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23677</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_23965 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23965">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:42364</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10696569</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:24084694</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Estradiol</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">estra-1,3,5(10)-triene-3,17-diol</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">272.178</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">272.38196</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C18H24O2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17?,18+/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VOXZDWNPVJITMN-WKUFJEKOSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12CC[C@]3(C)C(O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">oestradiol</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23965</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">estradiol</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_24431 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<rdfs:label xml:lang="en">chemical entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_24432 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24432">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A role played by the molecular entity or part thereof within a biological context.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological function</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">grouped_by_functions</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:24432</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_24532 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24532">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cyclic compound having as ring members atoms of carbon and at least of one other element.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChEBI:C03123</oboInOwl:hasDbXref>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterocycle</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterocyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:24532</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterocyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_24669 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24669">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any carboxylic acid with at least one hydroxy group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxy carboxylic acids</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxyacids</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:24669</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxy carboxylic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_24780 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24780">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_23677"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">imidazoles</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:24780</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">imidazoles</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_25000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33308"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactone</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactones</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lacton</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lakton</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Laktone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactona</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactonas</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:25000</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactone</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_25212 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25212">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:26619</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35220</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolite</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolites</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">primary metabolites</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">secondary metabolites</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:25212</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolite</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_25970 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25970">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26979"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">phenoxazines</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:25970</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">phenoxazine</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_2663 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_2663">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38830"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organoiodine compound that has formula C25H29I2NO3.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:1271711</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:1951-25-3</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01118</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:1951-25-3</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C06823</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D02910</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Amiodarone</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amiodarone</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C25H29I2NO3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:2663</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">amiodarone</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_26979 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_26979">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38166"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heterotricyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterotricyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:26979</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterotricyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_27171 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_27171">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38166"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heterobicyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterobicyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">two-ring heterocyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:27171</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterobicyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_27999 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_27999">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33675"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:27019</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:9616</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:64-77-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01124</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:2696</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07148</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00380</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-3907</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11835228</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11840346</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11911494</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12042355</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12355256</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15207658</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15317941</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15620874</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15655519</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16290322</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16426753</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19059420</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:20880646</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21178111</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21193530</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21471135</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21535124</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21712613</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21757329</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21827497</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21831467</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:22028182</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:22079696</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:DE1066575</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:GB808071</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US2968158</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:1984428</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Tolbutamide</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tolbutamide</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-Butyl-3-(p-methylphenylsulfonyl)urea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-Butyl-3-(p-tolylsulfonyl)urea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-Butyl-3-tosylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-p-Toluenesulfonyl-3-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">270.104</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">270.34800</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3-(p-Tolyl-4-sulfonyl)-1-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C12H18N2O3S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">JLRGJRBPOGGCBT-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(4-Methylbenzenesulfonyl)-N'-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(4-Methylphenylsulfonyl)-N'-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(p-Methylbenzenesulfonyl)-N'-butylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-Butyl-N'-(4-methylphenylsulfonyl)urea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-Butyl-N'-(p-tolylsulfonyl)urea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-Butyl-N'-p-toluenesulfonylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-n-Butyl-N'-tosylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Orinase (TN)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tolylsulfonylbutylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tolbutamida</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tolbutamide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tolbutamidum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:27999</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tolbutamide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_28794 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_28794">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38166"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A chromenone having the keto group located at the 2-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:101256</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23402</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:3906</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:41552</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:383644</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:91-64-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB04665</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:738</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gmelin:165222</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB01218</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C05851</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D07751</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00002460</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-2519</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MetaCyc:COUMARIN</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17988284</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19025869</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21046436</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21462332</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21798343</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:8735869</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:383644</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Coumarin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2H-chromen-2-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1,2-Benzopyrone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">146.037</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">146.14270</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">146.143</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-Propenoic acid, 3-(2-hydroxyphenyl)-, d-lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-Propenoic acid, 3-(2-hydroxyphenyl)-, delta-lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2H-1-Benzopyran-2-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2H-benzo[b]pyran-2-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5,6-Benzo-2-pyrone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Benzo-a-pyrone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Benzo-alpha-pyrone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C9H6O2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C=1C=CC=C2C1C=CC(=O)O2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coumarine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coumarinic anhydride</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cumarin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rattex</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tonka bean camphor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ZYGHJZDHTFUPRJ-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cis-o-Coumarinic acid lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">o-Hydroxycinnamic acid lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">o-hydroxycinnamic acid delta-lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:28794</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">coumarin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_29133 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29133">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33285"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:88093</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:125-73-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-36603</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17-methyl-9alpha,13alpha,14alpha-morphinan-3-ol</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(+)-3-hydroxy-N-methylmorphinan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">257.178</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">257.37066</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C17H23NO</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">JAQUASYNZVUNQP-PVAVHDDUSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12CCCC[C@]11CCN(C)[C@H]2Cc2ccc(O)cc12</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">d-3-hydroxy-N-methylmorphinan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dextrorphan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dextrorphane</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dextrorphanum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:29133</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dextrorphan</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_3219 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_3219">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A propanone that is propan-1-one substituted by a tert-butylamino group at position 2 and a 3-chlorophenyl group at position 1.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:2101062</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:34841-39-9</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:34911-55-2</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01156</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:435</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB01510</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C06860</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D07591</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-1267</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MetaCyc:CPD-3481</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12826985</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15876900</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:2101062</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Bupropion</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bupropion</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">239.108</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">239.74086</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C13H18ClNO</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNPPWIUOZRMYNY-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:3219</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bupropion</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33240 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33240">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37577"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">coordination entities</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">coordination entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">coordination compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33240</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">coordination entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33285 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33285">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroorganic entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organoelement compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33285</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroorganic entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33308 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33308">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35701"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13204</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23028</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:3408</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C02391</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Ester</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carboxylic ester</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic esters</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CO2R2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[*]C(=O)O[*]</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a carboxylic ester</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic acid esters</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33308</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic ester</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33575 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33575">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35605"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13428</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13627</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23027</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:17147560</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18433345</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic acids</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHO2R</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carbonsaeure</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carbonsaeuren</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karbonsaeure</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OC([*])=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RC(=O)OH</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acide carboxylique</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acides carboxyliques</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acido carboxilico</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acidos carboxilicos</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33575</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carboxylic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33579 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33579">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_23367"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main group compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main group molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33579</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main group molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33582 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33582">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33675"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon group molecular entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon group molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33582</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon group molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33675 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33675">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33579"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p-block compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p-block molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p-block molecular entitiy</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33675</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p-block molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33694 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33694">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33839"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A macromolecule formed by a living organism.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biopolymer</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biopolymere</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biomacromolecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biopolymers</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33694</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biomacromolecule</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33695 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33695">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33694"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">genetically encoded biomacromolecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">genetically encoded biopolymers</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">information biomacromolecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">information biopolymers</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">information macromolecule</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">information macromolecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33695</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">information biomacromolecule</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33696 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33696">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15986"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acids</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NA</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nukleinsaeure</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nukleinsaeuren</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acide nucleique</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acides nucleiques</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acido nucleico</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acidos nucleicos</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33696</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33697 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33696"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:63231-63-0</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acids</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNA</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNS</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ribonukleinsaeure</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pentosenucleic acids</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acids</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribose nucleic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">yeast nucleic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33697</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33832 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33832">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_72695"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any organic molecule that consists of atoms connected in the form of a ring.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic cyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33832</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic cyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33833 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33833">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroarenes</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hetarenes</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33833</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroarene</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33839 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33839">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36357"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Macromolecule</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecule</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polymer</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polymer molecule</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polymers</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33839</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecule</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_33976 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33976">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35217"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium coordination entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium coordination compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium coordination entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33976</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium coordination entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_34477 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_34477">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A 17beta-hydroxy steroid that is testosterone bearing an additional hydroxy substituent at the 6beta-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:63819</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:62-99-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB06259</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C14497</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LIPID_MAPS_instance:LMST02020054</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10574192</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15203039</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:22822673</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:2625776</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta,17beta-dihydroxyandrost-4-en-3-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta-Hydroxytestosterone</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(6beta,17beta)-6,17-dihydroxyandrost-4-en-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">304.204</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">304.42380</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4-androsten-6beta,17beta-diol-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta,17beta-Dihydroxyandrost-4-en-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta,17beta-dihydroxy-4-androsten-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta,17beta-dihydroxyandrost-4-en-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C19H28O3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">XSEGWEUVSZRCBC-ZVBLRVHNSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@@]12C[C@@H](O)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:34477</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6beta-hydroxytestosterone</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_34480 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_34480">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25970"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:225973</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:5725-91-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C13630</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-Ethoxyresorufin</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-ethoxy-3H-phenoxazin-3-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">241.074</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">241.24208</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-Ethoxyphenoxazone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C14H11NO3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCOc1ccc2nc3ccc(=O)cc3oc2c1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CRCWUBLTFGOMDD-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ethoxyresorufin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Resorufin ethyl ether</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:34480</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-ethoxyresorufin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_34593 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_34593">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35259"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:54340-62-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:424</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C13769</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bufuralol</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(+/-)-Bufuralol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">261.173</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">261.360</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C16H23NO2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCc1cccc2cc(oc12)C(O)CNC(C)(C)C</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SSEBTPPFLLCUMN-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dl-Bufuralol</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:34593</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#2_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bufuralol</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35134 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35134">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:PRX000002</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metalloprotein</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metalloproteine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metalloproteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35134</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metalloprotein</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35136 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35136">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35134"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:PRX000004</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">iron protein</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">iron proteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">iron-containing proteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35136</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">iron protein</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35137 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35137">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35136"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Conjugated proteins containing heme as the prosthetic group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:PRX000008</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hemoprotein</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Haemoprotein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Haemprotein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">haem protein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">haemoprotein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heme protein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hemeproteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hemoproteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35137</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hemoprotein</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35217 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35217">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36562"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alkaline earth coordination entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alkaline earth coordination compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alkaline earth coordination entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35217</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alkaline earth coordination entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35222 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35222">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24432"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A substance that diminishes the rate of a chemical reaction.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibitor</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibidor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibiteur</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibitors</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35222</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibitor</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35259 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35259">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38166"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:22721</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">benzofurans</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35259</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">benzofurans</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35501 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35501">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26979"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triazolobenzodiazepines</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35501</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triazolobenzodiazepine</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35605 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35605">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon oxoacids</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">oxoacids of carbon</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35605</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon oxoacid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35701 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35701">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:23960</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4859</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C00287</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ester</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[*]OC([*])=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">esters</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35701</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ester</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35868 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35868">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24669"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxy acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxy monocarboxylic acids</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35868</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxy monocarboxylic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_35972 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35972">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35868"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dihydroxy monocarboxylic acids</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:35972</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dihydroxy monocarboxylic acid</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36074 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36074">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35137"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:PRX000150</oboInOwl:hasDbXref>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">haem-thiolate protein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heme-thiolate proteins</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36074</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heme-thiolate protein</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36080 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36080">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33695"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:13677</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:14911</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">proteins</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36080</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36357 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36357">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_23367"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any molecular entity consisting of more than one atom.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polyatomic entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36357</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">polyatomic entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_3655 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_3655">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27171"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:47330</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:638882</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:95-25-0</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00356</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:626</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB14500</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07931</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00771</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-6011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:CLW</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10640318</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11727787</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12437348</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16763012</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16859676</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17621748</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21195386</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:23975871</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:24210069</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:25815637</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:6631711</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US2895877</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:638882</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Chlorzoxazone</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-1,3-benzoxazol-2-ol</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHLORZOXAZONE</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chlorzoxazone</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">168.993</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">169.56500</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-hydroxy-5-chlorobenzoxazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-2(3H)-benzoxazolone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-2-benzoxazolinone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-2-benzoxazolol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-2-benzoxazolone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chloro-2-hydroxybenzoxazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chlorobenzoxazolidone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-chlorobenzoxazolin-2-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C7H4ClNO2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oc1nc2cc(Cl)ccc2o1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TZFWDZFKRBELIQ-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chlorzoxane</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chlorzoxazona</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chlorzoxazone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chlorzoxazonum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:3655</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chlorzoxazone</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36562 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36562">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33240"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A coordination entity in which the central atom to which the ligands are attached comes from groups 1, 2, 13, 14, 15, 16, 17, or 18 of the periodic table.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main group coordination compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main-group coordination entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36562</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">main-group coordination entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36962 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36962">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33285"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organochalcogen compound</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organochalcogen compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36962</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organochalcogen compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_36963 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36963">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36962"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organochalcogen compound containing at least one carbon-oxygen bond.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:17586126</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organooxygen compound</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organooxygen compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:36963</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organooxygen compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_37577 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37577">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36357"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A molecular entity consisting of two or more chemical elements.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chemical compound</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroatomic molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:37577</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heteroatomic molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38163 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38163">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38166"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterotetracyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38163</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heterotetracyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38166 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38166">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:25429</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38075</oboInOwl:hasAlternativeId>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multi-ring heterocyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heteropolycyclic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38166</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic heteropolycyclic compound</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38179 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38179">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">monocyclic heteroarenes</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38179</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">monocyclic heteroarene</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38545 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38545">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35972"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:9670765</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:287714-41-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:17970755</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18509206</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:19724024</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:19956889</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23806820</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23881596</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23944632</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24072337</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24076283</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24076297</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24156555</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24163149</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24230979</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24253250</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24259612</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24304551</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24333476</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24353409</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24410968</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24417785</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24434545</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24440231</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24440960</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24444439</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24452083</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24456217</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24467235</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01098</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB15230</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D08492</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US2013035316</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:9670765</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Rosuvastatin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C22H28FN3O6S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CC(C)c1nc(nc(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)N(C)S(C)(=O)=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rosuvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38545</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rosuvastatin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38559 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38559">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36074"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COMe:PRX000645</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cytochrome P450</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CYP</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">P450 protein</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cytochrome P-450</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38559</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cytochrome P450</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38561 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38561">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60911"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:9168031</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:93957-54-1</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11273020</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:12147804</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18410471</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18413661</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18452779</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18936176</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23212095</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23846727</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01095</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:93957-54-1</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C07014</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D07983</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US4739073</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:WO8402131</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Fluvastatin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(+-)-fluvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C24H26FNO4</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cranoc</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluvastatina</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluvastatine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluvastatinum</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rac-(3R,5S)-fluvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38561</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluvastatin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38597 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38597">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_68452"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triazole</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C2H3N3</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38597</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_38830 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38830">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35259"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:38830</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-benzofurans</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_39548 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_39548">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35972"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:2910</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:39538</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:8373630</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:134523-00-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11693468</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:15012735</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18720283</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01076</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB05006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:134523-00-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C06834</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D07474</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:117</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:EP409281</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US5273995</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:8373630</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Atorvastatin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atorvastatin</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atorlip</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C33H35FN2O5</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(O)=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=XUKUURHRXDUEBC-KAYWLYCHSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atorvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atorvastatina</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atorvastatine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atorvastatinum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:39548</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atorvastatin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_40303 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_40303">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18946"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as a antilipemic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:40299</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:6544</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:3631989</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:75330-75-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11375168</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11389707</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11483865</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18642339</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:24093797</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00227</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB14372</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG COMPOUND:C07074</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:75330-75-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D00359</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00000547</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:803</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:CN103172602</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:WO2013090461</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:4720754</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Lovastatin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LOVASTATIN</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lovastatin</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6alpha-methylcompactin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C24H36O5</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MK-803</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ML-530B</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mevacor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mevinolin</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:40303</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lovastatin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_4470 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_4470">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38163"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:125-71-3</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00514</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB01920</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C06947</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D03742</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17461892</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18198471</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:24269965</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:88549</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Dextromethorphan</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3-methoxy-17-methylmorphinan</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dextromethorphan</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">271.194</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">271.39724</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C18H25NO</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DXM</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MKXZASYAUGDDCJ-CGTJXYLNSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2Cc2ccc(OC)cc12</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">d-Methorphan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">delta-Methorphan</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4470</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dextromethorphan</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_45863 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_45863">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:45862</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:7887</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:33069-62-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01229</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:2044</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07394</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00491</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KNApSAcK:C00002365</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:TA1</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Paclitaxel</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Paclitaxel</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">853.331</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">853.90618</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C47H51NO14</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RCINICONZNJXQF-MZXODVADSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TAXOL</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Taxol A</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">taxol</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:45863</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">paclitaxel</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_46081 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_46081">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38597"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It has been shown to exhibit antifungal activity.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:46079</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:5099</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:4269710</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:86386-73-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11366931</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:16822276</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23171950</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:23793863</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00196</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB14342</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D00322</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:TPF</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:GB2099818</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US4404216</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:7311650</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Fluconazole</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biozole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C13H12F2N6O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diflucan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elazor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Triflucan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluconazol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluconazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluconazolum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:46081</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fluconazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_47381 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_47381">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4507</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:47380</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:2146636</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:15307-86-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00586</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:865</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB14724</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C01690</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D07816</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-2160</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:DIF</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11322639</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:1502708</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:23777257</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:7838674</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:NL6604752</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US3558690</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:2146636</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Diclofenac</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-[(2,6-dichlorophenyl)amino]benzeneacetic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diclofenac</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-((2,6-dichlorophenyl)amino)benzeneacetic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">296.14900</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">353.022</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C16H13Cl2NO4</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DCOPUUMXTXDBNB-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[2-(2,6-dichloroanilino)phenyl]acetic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diclofenac</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diclofenac acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diclofenaco</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diclofenacum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:47381</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">diclofenac</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_48339 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48339">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24780"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A N-carbonylpiperazine that has formula C26H28Cl2N4O4.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:634785</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01026</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C26H28Cl2N4O4</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:48339</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ketoconazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_48684 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48684">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27171"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">benzothiazepines</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:48684</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">benzothiazepine</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_50860 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50860">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33582"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any molecular entity that contains carbon.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:25700</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:33244</oboInOwl:hasAlternativeId>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">.</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic compounds</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic entity</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecular entities</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:50860</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecular entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_51234 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_51234">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33976"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium halides</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:51234</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium halide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_51602 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_51602">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25970"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:174850</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:635-78-9</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-hydroxy-3H-phenoxazin-3-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">213.043</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">213.18892</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-Hydroxy-3H-phenoxazin-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7-Hydroxyphenoxazin-3-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C12H7NO3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HSSLDCABUXLXKM-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C12H7NO3/c14-7-1-3-9-11(5-7)16-12-6-8(15)2-4-10(12)13-9/h1-6,14H</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oc1ccc2nc3ccc(=O)cc3oc2c1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Resorufine</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:51602</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">resorufin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_59613 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59613">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:4198042</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:64118-84-9</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10027798</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10709153</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10807502</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12966366</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:14609740</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15139759</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15265128</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15455182</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17123753</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18548238</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:2118185</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:9226412</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:9862754</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:4198042</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">{2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(o-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">311.012</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">312.14800</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4'-OH DCF</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4'-hydroxy diclofenac</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C14H11Cl2NO3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KGVXVPRLBMWZLG-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:59613</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4'-hydroxydiclofenac</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_59999 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chemische Substanz</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:59999</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chemical substance</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_60004 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60004">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mischung</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:60004</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mixture</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_6076 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_6076">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38597"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A dioxolane that has formula C35H38Cl2N8O4.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChEMBL:17194821</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:84625-61-6</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01167</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:84625-61-6</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D00350</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Itraconazole</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Itraconazole</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C35H38Cl2N8O4</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Itrizole (TN)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oriconazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sporanox (TN)</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:6076</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">itraconazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_60911 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60911">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60004"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A racemate is an equimolar mixture of a pair of enantiomers.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">melange racemique</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">racemates</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">racemic mixture</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:60911</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">racemate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_63799 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63799">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33832"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:5719-85-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HMDB:HMDB06408</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16493553</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:2867981</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">286.099</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">286.34700</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C12H18N2O4S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hydroxymethyltolbutamide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hydroxytolbutamide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Methylhydroxytolbutamide</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SJRHYONYKZIRPM-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:63799</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4-hydroxytolbutamide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_63840 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63840">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22715"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A sulfoxide that is omeprazole in which one of the methyl hydrogens at position 5 on the pyridine ring is substituted by a hydroxy group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:92340-57-3</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19166730</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:21546194</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:7781266</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:8550990</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:9916309</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:8439890</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(4-methoxy-6-{[(5-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl}-5-methylpyridin-3-yl)methanol</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">361.110</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">361.41500</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-Methoxy-2-(((4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C17H19N3O4S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CMZHQFXXAAIBKE-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COc1ccc2[nH]c(nc2c1)S(=O)Cc1ncc(CO)c(OC)c1C</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hydroxyomeprazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C17H19N3O4S/c1-10-15(18-7-11(8-21)16(10)24-3)9-25(22)17-19-13-5-4-12(23-2)6-14(13)20-17/h4-7,21H,8-9H2,1-3H3,(H,19,20)</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:63840</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5'-hydroxyomeprazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_63859 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63859">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A taxane diterpenoid that consists of paclitaxel bearing an additional hydroxy substituent at the 6alpha-position.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:153212-75-0</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:8105272</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(2alpha,5beta,6alpha,7beta,10beta,13alpha)-4,10-diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,6,7-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6-hydroxytaxol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6alpha-hydroxypaclitaxel</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6alpha-hydroxytaxol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">869.326</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">869.90550</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C47H51NO15</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45-,46+,47+/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NDCWHEDPSFRTDA-FJMWQILYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)[C@H](O)[C@H]1OC[C@@]21OC(C)=O)C3(C)C</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:63859</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6-hydroxypaclitaxel</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_6636 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_6636">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51234"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A magnesium salt comprising of two chlorine atoms bound to a magnesium atom.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:7786-30-3</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gmelin:9305</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07755</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MolBase:1868</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:8128169</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium dichloride</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">93.923</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">95.21040</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cl2Mg</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/2ClH.Mg/h2*1H;/q;;+2/p-2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magnesium chloride</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magnesium chloride anhydrous</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magnesiumchlorid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MgCl2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TWRXJAOTZQYOKJ-UHFFFAOYSA-L</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[Mg++].[Cl-].[Cl-]</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">[MgCl2]</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:6636</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">magnesium dichloride</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_68452 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_68452">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38179"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Azole</oboInOwl:hasDbXref>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">azoles</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:68452</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">azole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_6931 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_6931">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:59467-70-8</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:1802</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07524</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00550</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-5200</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Midazolam</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">325.078</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">325.768</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C18H13ClFN3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DDLIGBOFAVUZHB-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">buccolam</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mezolam</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">midazolam HCl</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">midazolam hydrochloride</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:6931</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#2_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Midazolam</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_72695 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_72695">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecules</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:72695</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecule</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_7565 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7565">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:497773</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:21829-25-4</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01115</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug_Central:1922</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07266</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00437</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LINCS:LSM-4176</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Nifedipine</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nifedipine</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">346.116</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">346.33460</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adalat</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adapine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C17H18N2O6</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coracten</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HYIMSNHJOBLJNT-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nifecard</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nifecor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nifedipres</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Procardia</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipino</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipinum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:7565</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipine</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_7772 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7772">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60911"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:3628192</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:73590-58-6</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00338</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:C07324</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG:D00455</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11060758</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11208500</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11210716</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11304936</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11321383</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11395292</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11404722</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11459434</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11568514</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11700946</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11774962</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11807212</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11851112</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11903739</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11962536</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12072663</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12135028</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12235248</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12495367</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:12683615</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:13680386</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:14616415</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:14708212</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:14725575</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15004262</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15125696</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15586641</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15598025</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15684503</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15707461</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15774534</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16080278</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16129922</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16259581</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16276979</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16380990</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16386527</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16397810</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16440530</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:16998872</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17049542</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17384694</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:17532167</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18294333</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18366242</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18416943</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18448060</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18498918</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18520598</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18571645</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18616070</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18793272</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:18818790</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19150046</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19166730</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19176055</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19236757</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19327607</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19383986</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19434360</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19470853</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19517893</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19746659</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19796313</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19801857</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19937171</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:EP5129</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US4255431</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US5693818</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:3628192</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Omeprazole</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rac-5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Antra</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Audazol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Belmazol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ceprandal</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Danlox</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Desec</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elgam</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Emeproton</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gasec</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gastrimut</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indurgan</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inhibitron</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Losec</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMEP</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMP</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMZ</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Olit</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Omapren</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Omebeta</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prazidec</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Procelac</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sanamidol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ulceral</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ulcesep</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ultop</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">omeprazol</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">omeprazole</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">omeprazolum</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:7772</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">omeprazole</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_82814 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_82814">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48684"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A lactam that is 2,3-dihydro-1,5-benzothiazepin-4(5H)-one in which positions 2 and 3 are substituted by 4-methoxyphenyl and acetoxy, respectively, while the hydrogen attached to the nitrogen is substituted by a 2-(dimethylamino)ethyl group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:34933-06-7</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:25644899</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C22H26N2O4S</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COc1ccc(cc1)C1Sc2ccccc2N(CCN(C)C)C(=O)C1OC(C)=O</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=HSUGRBWQSSZJOP-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:82814</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_9150 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_9150">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18946"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:45577</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:4768037</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:79902-63-9</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:11336576</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:12827636</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:14561068</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:14973129</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18199328</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18688862</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CiteXplore:18936176</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00641</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:79902-63-9</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D00434</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PDBeChem:SIM</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:EP33538</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patent:US4444784</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Simvastatin</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SIMVASTATIN</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simvastatin</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C25H38O5</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MK-733</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simvastatina</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simvastatine</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simvastatinum</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zocor</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">simvastatin</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:9150</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">simvastatin</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_9674 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_9674">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35501"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A triazolobenzodiazepine that has formula C17H12Cl2N4.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chebi.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:1226643</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ChemIDplus:28911-01-5</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB00897</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KEGG DRUG:D00387</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Triazolam</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">chebi_ontology</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C17H12Cl2N4</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Halcion</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">InChIKey=JOFWLTCLBGQGBO-UHFFFAOYSA-N</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:9674</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triazolam</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHMO_0002013 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHMO_0002013">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0302886"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A separation method where components of a sample are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. Samples are spun at >5000 rpm.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chmo.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">burchh</oboInOwl:created_by>
<oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009-06-19T02:03:14Z</oboInOwl:creation_date>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">high speed centrifugation</oboInOwl:hasExactSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHMO:0002013</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">high-speed centrifugation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHMO_0002914 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHMO_0002914">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The process of one material (absorbate) being retained by another (absorption).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/chmo.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">REX:0000188</oboInOwl:hasAlternativeId>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHMO:0002914</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gold Book, somewhat modified. It goes on "The process of one material (absorbate) being retained by another (absorbent); this may be the physical solution of a gas, liquid, or solid in a liquid, attachment of molecules of a gas, vapour, liquid, or dissolved substance to a solid surface by physical forces, etc."</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">absorption of material</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0000001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000010"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell line cell</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture</obo:IAO_0000115>
<obo:IAO_0000115>A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
</obo:IAO_0000115>
<obo:IAO_0000117>Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<rdfs:comment>A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures. </rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell line cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0000031">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000112>He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene".
Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'.</obo:IAO_0000112>
<obo:IAO_0000115>A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).</obo:IAO_0000115>
<obo:IAO_0000116>In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here:
http://code.google.com/p/clo-ontology/wiki/Cell_Lines</obo:IAO_0000116>
<obo:IAO_0000117>MB, SS, JZ, MAH, BP, CS, YH</obo:IAO_0000117>
<rdfs:comment>The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.).
The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history. As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use.</rdfs:comment>
<rdfs:label xml:lang="en">cell line</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0002172 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0002172">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:CLO_0000178>LCL-1170</obo:CLO_0000178>
<obo:IAO_0000118>Caco-2</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<rdfs:comment>disease: colorectal adenocarcinoma</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Caco-2 cell</rdfs:label>
<rdfs:seeAlso>ATCC: HTB-37</rdfs:seeAlso>
<rdfs:seeAlso>CHEMBL: CHEMBL3307519</rdfs:seeAlso>
<rdfs:seeAlso>CVCL: CVCL_0025</rdfs:seeAlso>
<rdfs:seeAlso>EFO: EFO_0001099</rdfs:seeAlso>
<rdfs:seeAlso>HyperCLDB: cl618</rdfs:seeAlso>
<rdfs:seeAlso>MeSH: D018938</rdfs:seeAlso>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0002421 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0002421">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000118>CHO</obo:IAO_0000118>
<obo:IAO_0000118>Chinese Hamster Ovary cell</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo-merged.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHO cell</rdfs:label>
<rdfs:seeAlso>HyperCLDB: cl721</rdfs:seeAlso>
<rdfs:seeAlso>MeSH: D016466</rdfs:seeAlso>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0007331 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0007331">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000118>LLC-PK subscript(1)</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LLC-PK subscript(1) cell</rdfs:label>
<rdfs:seeAlso>ATCC: CL-101</rdfs:seeAlso>
<rdfs:seeAlso>HyperCLDB: cl3221</rdfs:seeAlso>
<rdfs:seeAlso>MeSH: D018374</rdfs:seeAlso>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0007646 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0007646">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000118>MDCK</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MDCK cell</rdfs:label>
<rdfs:seeAlso>HyperCLDB: cl5078</rdfs:seeAlso>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CLO_0037237 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CLO_0037237">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:CLO_0037192>Amelogenin: X; CSF1PO: 11,12; D13S317: 12; D16S539: 9; D18S51: 18; D21S11: 28,30.2; D3S1358: 15,17; D5S818: 8,9; D7S820: 11,12; D8S1179: 12,14; FGA: 23; Penta D: 9,10; Penta E: 7,15; TH01: 7,9.3; TPOX: 11; vWA: 16,19</obo:CLO_0037192>
<obo:IAO_0000118>293</obo:IAO_0000118>
<obo:IAO_0000118>293 HEK</obo:IAO_0000118>
<obo:IAO_0000118>HEK 293</obo:IAO_0000118>
<obo:IAO_0000118>HEK-293</obo:IAO_0000118>
<obo:IAO_0000118>HEK293</obo:IAO_0000118>
<obo:IAO_0000119>WEB: http://hek293.com/</obo:IAO_0000119>
<obo:IAO_0000119>WEB: http://web.expasy.org/cellosaurus/CVCL_0045</obo:IAO_0000119>
<obo:IAO_0000119>WEB: https://www.atcc.org/Products/All/CRL-1573.aspx</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo-merged.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">293-derived cell</rdfs:label>
<rdfs:seeAlso>ATCC: CRL-1573</rdfs:seeAlso>
<rdfs:seeAlso>RRID: CVCL_0045</rdfs:seeAlso>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CL_0000010 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000010">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000578"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell</obo:IAO_0000111>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell in vitro that is or has been maintained or propagated as part of a cell culture.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell</oboInOwl:hasOBONamespace>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. </rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CL_0000578 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000578">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">experimentally modified cell in vitro</obo:IAO_0000111>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/clo.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell</oboInOwl:hasOBONamespace>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">experimentally modified cell in vitro</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000030"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000002"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000003"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000004"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000011"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000014"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/APOLLO_SV_00000461"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A potential drug-drug interaction (PDDI) is an information content entity that specifies the possibility of a drug-drug interaction based on either reasonable extrapolation about drug-drug interaction mechanisms or a data item created by clinical studies, clinical observation or physiological experiment.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">potential drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000112 xml:lang="en">the DDI mechanism, the risk of it causing a clinical effect, the clinical effect brought about by that DDI, factor's that modify the probability of it occuring</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">An information content entity that is about a drug-drug interaction.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">DDI description</obo:IAO_0000118>
<rdfs:label xml:lang="en">drug-drug interaction description</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000002 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000002">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000027"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is about a biological process</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">mechanistic assertion data item</obo:IAO_0000118>
<rdfs:label xml:lang="en">data item about biological process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000003 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000003">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is about a drug-drug interaction and the creation of which was triggered by an observation outside a controlled context (e.g. a clinical trial).</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">observational data item about drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000004 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000004">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000027"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is about a biological process and that is the specified output of a clinical study.</obo:IAO_0000115>
<rdfs:label xml:lang="en">physiological observation from clinical study data item</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000005 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000005">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is the output of a process of estimating, beyond the original observation range, the value of a variable on the basis of its relationship with another variable.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">https://en.wikipedia.org/w/index.php?title=Extrapolation&oldid=690284752</obo:IAO_0000119>
<rdfs:label xml:lang="en">data item from extrapolation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000006 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000006">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000034"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001007"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 xml:lang="en">A biological process that realizes the function of the gastrointestinal system (or any organ that is a part of it.). This includes digestion of ingested substances, absorption and eliminating waste.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">Physiological activity and functions of the gastrointestinal system as a whole or of any of its parts, including digestion, absorption and eliminating waste.</rdfs:comment>
<rdfs:label xml:lang="en">gastrointestinal functioning</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000007 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000007">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
<obo:IAO_0000112 xml:lang="en">"Use only if benefit outweighs risk: “When a systemic dose of epinephrine is given to a person on one of these nonselective beta-blockers, an acute hypertensive reaction is almost certain. Systolic BPs of 250 mm/Hg are not uncommon. Most people can probably withstand a short episode of such a hypertensive reaction without permanent sequelae, but strokes have occurred in susceptible patients. Thus, it is best to avoid this reaction if possible. If a patient is likely to receive systemic epinephrine, it would be prudent to use a cardioselective beta-blocker.” (Title: Individualized Drug Interaction Alerts; Authors: Daniel C. Malone , University of Arizona; John Horn, Philip Hansten, University of Washington)</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">No precaution: “If the NSAID is being used as an analgesic or antipyretic, it would be prudent to use an alternative such as acetaminophen. In some people, acetaminophen can increase the anticoagulant effect of warfarin, so monitor the INR if acetaminophen is used in doses over 2 g/day for a few days. For more severe pain consider short-term opioids in place of the NSAID.“ (Title: Individualized Drug Interaction Alerts; Authors: Daniel C. Malone , University of Arizona; John Horn, Philip Hansten, University of Washington)</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">A evidence-based plan specification that specifies processes to prevent or mitigate a drug-drug interaction</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">management option</obo:IAO_0000118>
<obo:MPIO_0000001 xml:lang="en">Evidence-based strategy to mitigate the potential clinical consequences of a drug-drug interaction; e.g., use only if benefit outweighs risk, assess risk and take action if necessary, no special precautions.</obo:MPIO_0000001>
<efo:alternative_term xml:lang="en">recommended action</efo:alternative_term>
<rdfs:comment xml:lang="en">An instance of this entity would represent an optional recommendation for the clinical management of patients who are exposed or about to be exposed to a potential DDI. Management options may be generated by expert opinion, consensus, and/or a review and synthesis of relevant evidence.</rdfs:comment>
<rdfs:label xml:lang="en">drug-drug interaction management option</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000008 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000008">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
<owl:Restriction>
<owl:onProperty>
<rdf:Description>
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
</rdf:Description>
</owl:onProperty>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000311"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A drug-drug interaction that has been the subject of a case report or study.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">interaction occured</obo:IAO_0000118>
<rdfs:comment xml:lang="en">An instance of a drug-drug interaction that has been identified in case report or study.</rdfs:comment>
<rdfs:label xml:lang="en">reported drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000009 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000009">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is the outcome of running a kinetic model and that states that drug A has some effects on the absorption, metabolism and elimination of drug B.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">Evidence from a kinetic model that a drug-Y has some effect on the absorption, metabolism and elimination of drug-X.</rdfs:comment>
<rdfs:label xml:lang="en">pharmacokinetic interaction signal</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000010 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000010">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">Bioavailability is a disposition that is borne by a drug product and is realized by the process of a proportion of the active pharmaceutical ingredient in that drug product reaching systemic circulation.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">bioavailability</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000011 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000011">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An information content entity that makes a statement about a drug product being an object drug in a drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">object drug information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000012 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000012">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">The role that inheres in a drug product or drug ingredient and that is realized by being affected by another drug pharmacokinetically or pharmacodynamically in a drug drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Daniel C. Malone</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Jodi Schneider</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Richard D. Boyce</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<dc:source xml:lang="en">http://www.hanstenandhorn.com/article-d-i.html</dc:source>
<rdfs:label xml:lang="en">object drug role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000013 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000013">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">The role that inheres in a drug product or drug ingredient that is realized by affecting another drug pharmacokinetically or pharmacodynamically in a drug drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Daniel C. Malone</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Jodi Schneider</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Richard C. Boyce</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<dc:source xml:lang="en">http://www.hanstenandhorn.com/article-d-i.html</dc:source>
<rdfs:label xml:lang="en">precipitant drug role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000014 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000014">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An information content entity that makes a statement about a drug product being an precipitant drug in a drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">precipitant drug information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000015 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000015">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000000"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0017144"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000000"/>
<obo:IAO_0000115 xml:lang="en">A potential drug drug interaction that is about a drug metabolism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">metabolic potential drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000016 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000016">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A disposition inhering in a drug product that when realized is realized by processes that negatively affect the safety or the efficacy of the drug product, or increase its toxicity..</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">narrow therapeutic index</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000017 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000017">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000015"/>
<obo:IAO_0000115 xml:lang="en">A metabolism induction potential drug-drug interaction that is about an decrease of metabolic activity because of either a decreased expression of the enzyme or inference with how the enzyme contributes to the metabolic process.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">metabolism inhibition potential drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000018 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000018">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000015"/>
<obo:IAO_0000115 xml:lang="en">A metabolism induction potential drug-drug interaction that is about an increase of an enzyme participating in the metabolic process.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">metabolism induction potential drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000019 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000019">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.obofoundry.org/ro/ro.owl#proper_part_of"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000115 xml:lang="en">A material entity that is either drug product or an ingredient thereof and that participates in a drug-drug interaction.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">Drug participant in drug-drug interaction</obo:IAO_0000118>
<rdfs:comment xml:lang="en">A drug entity that participate in a drug-drug interaction but for which its role is not assignable as a precipitant or object.</rdfs:comment>
<rdfs:label xml:lang="en">material entity participant in drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000020 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000020">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000117"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000021"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A biological process that results in a clinically meaningful change to the response of at least one co-administrated drug.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">DDI</obo:IAO_0000118>
<rdfs:comment xml:lang="en">A clinically meaningful alteration in the exposure and/or response to a drug (object drug) that has occurred as a result of the co-administration of another drug (precipitant drug)Oates JA. Chapter 5. Goodman and Gilman 11th ed (2006):117–36; Hines. Response can refer to either precipitating an adverse event or altering the therapeutic effect of the object drug. Although some DDIs may be used for therapeutic benefit, this paper focuses on those with adverse clinical consequences. (based on the 2013 DDI conference series) / has participant some mechanism.</rdfs:comment>
<rdfs:label xml:lang="en">drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000021 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000021">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000115 xml:lang="en">A planned process of administering more than one drug to the same individual over a specific time interval.</obo:IAO_0000115>
<obo:IAO_0000232 xml:lang="en">This class currently does not have a restriction. One candidate restriction is a necessary condition: 'has participant at some time' min 2 'drug product'. I was not able to find an OWL reasoner for Protege 5 that supports cardinality restrictions.</obo:IAO_0000232>
<rdfs:comment xml:lang="en">An instance of this occurs when at least two or more drugs are taken in a specific time interval and the individual time interval for each drug administration overlaps with the other drug's or drugs' time interval(s). (SG1)</rdfs:comment>
<rdfs:label xml:lang="en">drug co-administration</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000022 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000022">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000112 xml:lang="en">Non-steroidal anti-inflammatory drugs (NSAIDs) have antiplatelet effects which increase the bleeding risk when combined with oral anticoagulants such as warfarin. The antiplatelet effect of NSAIDs lasts only as long as the NSAID is present in the circulation, unlike aspirin’s antiplatelet effect, which lasts for up to 2 weeks after aspirin is discontinued.</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">Timolol is a nonselective beta-blocker, and timolol eye drops have been shown to produce systemic beta-blockade. Timolol is metabolized by CYP2D6, and patients who are deficient in CYP2D6 (PMs) have been shown to develop higher timolol plasma concentrations following timolol ophthalmic aqueous drops.</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">An information content entity that represents a drug interaction as a directional series of molecular processes.</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">This is an information content entity that is about a clinically measurable drug-drug interaction.</obo:IAO_0000116>
<obo:IAO_0000118 xml:lang="en">drug interaction mechanism</obo:IAO_0000118>
<obo:MPIO_0000001 xml:lang="en">An assertion about the process or the processes by which a drug-drug interaction clinical consequence occurs.</obo:MPIO_0000001>
<rdfs:comment xml:lang="en">An instance of this entity would represent the biochemical process by which pharmacokinetic or pharmacodynamic DDI is thought to occur.</rdfs:comment>
<rdfs:label xml:lang="en">mechanism of interaction information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000023 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000023">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000021"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An information content entity that is about a drug co-administration and is intended to be specified input into the assessment of whether a drug-drug interaction exists or not.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">An instance of this type represents a information artifact used to establish knowledge for or against the existence of a drug-drug interaction.</rdfs:comment>
<rdfs:label xml:lang="en">drug-drug interaction evidence</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000024 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000024">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000000"/>
<obo:IAO_0000115 xml:lang="en">A potential drug-drug interaction that is causally linked to an elevated risk of an adverse event that warrants a drug-drug interaction management option.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">Alternative definitions use the risk of harm instead of the risk of an AE.</rdfs:comment>
<rdfs:label xml:lang="en">clinically relevant potential drug-drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000025 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000025">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000026"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A scalar measurement datum that is the specified outcome of a drug bioavailability assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">F</obo:IAO_0000118>
<rdfs:label xml:lang="en">bioavailability measurement datum</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000026 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000026">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000010"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An assay with the objective to capture information about the bioavailability of an active ingredient in a drug product.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug bioavailability assay</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000030">
<rdfs:subClassOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#ObsoleteClass"/>
<obo:IAO_0000115 xml:lang="en">An entity that is the result of a drug-drug interaction.</obo:IAO_0000115>
<obo:IAO_0000231 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000226"/>
<obo:IAO_0100001 rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000125"/>
<rdfs:label xml:lang="en">obsolete_drug-drug interaction effect</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000031">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">It is a disposition that is borne by drug product and is realized by the metabolism of the active pharmaceutical ingredient in that drug product before entering systemic circulation, when ingested.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">first pass effect disposition</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000032 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000032">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000031"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An assay with the objective to capture information about the first pass metabolism of an active ingredient in a drug product.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug first pass metabolism assay</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000033 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000033">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000032"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A scalar measurement datum that is the specified outcome of a drug first pass metabolism assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">first pass metabolism measurement datum</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000034 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000034">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
<obo:IAO_0000115 xml:lang="en">Absorbability is a disposition that is borne by a material entity that if realized is realized by the material entity taken up by another material entity in a different state of matter.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Daintith J (ed.): A Dictionary of Chemistry. 2008. Oxford University Press, Oxford UK.</obo:IAO_0000119>
<rdfs:label xml:lang="en">absorbability</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000035 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000035">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000034"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An assay with the objective to capture information about the absorbability of an active ingredient in a drug product.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug absorbability assay</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000036 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000036">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000035"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A a scalar measurement datum that is the specified outcome of an drug absorbability assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">AUC</obo:IAO_0000118>
<rdfs:label xml:lang="en">absorbability measurement datum</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000037 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000037">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An assay that measures the maximum concentration of an active ingredient of a drug product in a specified compartment of the body of an organism after the first dose of the drug product has been administered.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug maximum concentration assay</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000038 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000038">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000037"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<obo:IAO_0000115 xml:lang="en">A scalar measurement datum that is the specified outcome of a drug maximum concentration assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Cmax</obo:IAO_0000118>
<rdfs:label xml:lang="en">drug maximum concentration measurement datum</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000039 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000039">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000427"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A role that is borne by the enzyme responsible for 50% or more of the active pharmaceutic ingredient or metabolite’s total clearance from the body. The role role is realized by the metabolic process of the active pharmaceutical ingredient or metabolite.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">primary total clearance enzyme role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000040 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000040">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">A role that is borne by the enzyme responsible for 50% or more of the active pharmaceutic ingredient or metabolite’s total metabolic clearance from the body.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Anuj Shah</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">primary metabolic clearance enzyme role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000042 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000042">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000001"/>
<obo:IAO_0000115 xml:lang="en">A drug-drug interaction description that is part of a drug package insert.</obo:IAO_0000115>
<rdfs:label xml:lang="en">drug-drug interaction description from drug package insert</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000043 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000043">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000042"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000045"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A drug-drug interaction description from a drug package insert for an FDA approved drug.</obo:IAO_0000115>
<rdfs:label xml:lang="en">drug-drug interaction description from FDA label information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000044 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000044">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000310"/>
<obo:IAO_0000115 xml:lang="en">A document that is provided along with a medication and that gives additional information about that medication.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">https://en.wikipedia.org/w/index.php?title=Package_insert&oldid=699801598</obo:IAO_0000119>
<rdfs:label xml:lang="en">drug package insert</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000045 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000045">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000044"/>
<obo:IAO_0000115 xml:lang="en">A drug package insert for FDA-approved drugs that gives information about the drug, including the approved doses and how it's to be given to treat the medical condition for which it was approved.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">FDA drug label</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">http://www.fda.gov/forpatients/other/offlabel/default.htm</obo:IAO_0000119>
<rdfs:label xml:lang="en">U.S. Food and Drug Administration drug label</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000046 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000046">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000209"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An area under curve in a plot of concentration of granular part of a drug product in some matrix (medium) against time.</obo:IAO_0000115>
<rdfs:label xml:lang="en">pharmacokinetic area under curve</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000047 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000047">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000044"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000046"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that is part of a drug package insert and that is about a pharmacokinetic area under the curve measurement result.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug package AUC information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000048 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000048">
<rdfs:subClassOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#ObsoleteClass"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that provides statements or data that are used to support or refute an assertion.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Standards Development Working Group of the "Addressing PDDI Evidence Gaps" porject.</obo:IAO_0000119>
<rdfs:label xml:lang="en">obsolete_evidence information content entity</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000049 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000049">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000046"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that is about a pharmacokinetic area under curve.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">AUC information</obo:IAO_0000118>
<rdfs:label xml:lang="en">pharmacokinetic area under curve information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000050 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000050">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000049"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:minQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">2</owl:minQualifiedCardinality>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000046"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic area under curve information that is about at least 2 area under curve measurments and the time series shows an increase of the area under curve.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">information about increase of pharmacokinetic area under the curve</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000051 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000051">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000049"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:minQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">2</owl:minQualifiedCardinality>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000046"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic area under curve information that is about at least 2 area under curve measurments and the time series shows a decrease of the area under curve.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">information about decrease of pharmacokinetic area under the curve</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000052 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000052">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 xml:lang="en">A biological process that has as a participant a part of a drug product and includes absorption, distribution, metabolism and excretion of that substance.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">"Addressing PDDI Evidence Gaps" Standards Development Group.</obo:IAO_0000119>
<rdfs:label xml:lang="en">pharmacokinetic process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000053 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that is used to support or refute an assertion.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">"Addressing PDDI Evidence Gaps" Standards Development Group</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information content entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000054 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000054">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000030"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000142"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000295"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that is part of an evidence information content entity and mentions the specified input to an assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">"Addressing PDDI Evidence Gaps" Standards Development Group</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence material information</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000055 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000055">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000027"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
<obo:IAO_0000115 xml:lang="en">A data item that is part of an evidence information content entity and is the specified output of an assay.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">"Addressing PDDI Evidence Gaps" Standards Development Group</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence data item</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000056 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000056">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_Clinical_Trial</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from clinical study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000057 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000057">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_36080"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697"/>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000031"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process, as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_ID</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from drug metabolism identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000058 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000058">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0009892"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_36080"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_36080"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000031"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process, as it's specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_Inhibit</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from drug metabolism inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000059 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000059">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Trans_Prot_ID</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from transport protein identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000060 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000060">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of drug component transporter.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Trans_Prot_Inhibit</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from transport protein inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000061 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000061">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OAE_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000031"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that was triggered by an adverse drug event.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_Case_Report_ADE</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from observation-based adverse drug event report</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000062 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000062">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0300311"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an observation design.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_Observational</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from observational study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000063 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000063">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000031"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_ID_Cyp450</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 drug metabolism identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000064 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000064">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0000031"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has a cell line as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Enz_ID_Cyp450_Hum_Recom</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 recombinant drug metabolism identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000065 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000065">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0000031"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/GO_0042571"/>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35222"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has chemical inhibitors as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Met_Enz_ID_Cyp450_Hum_Recom_Chem</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 recombinant drug metabolism identification experiment using chemical inhibitors</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000066 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000066">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0000031"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0042571"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35222"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has antibody inhibitors as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Met_Enz_ID_Cyp450_Hum_Recom_Antibody</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 recombinant drug metabolism identification experiment using antibody inhibitors</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000067 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000067">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000659"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117>Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 human microsome drug metabolism identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000068 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000068">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/GO_0042571"/>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35222"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000659"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has chemical inhibitors as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 human microsome drug metabolism identification experiment using chemical inhibitors</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000069 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000069">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0042571"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35222"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000659"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has antibody inhibitors as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Antibody</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 human microsome drug metabolism identification experiment using antibody inhibitors</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000070 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000070">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0009892"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000031"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_Inhibit_Cyp450</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 metabolic enzyme inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000071 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000071">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_CT_DDI</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from drug-drug interaction clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000072 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000072">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Class>
<owl:complementOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:hasValue rdf:resource="http://purl.obolibrary.org/obo/OBI_0302900"/>
</owl:Restriction>
</owl:complementOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input and does not have group randomization as a part.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_PK_DDI_NR</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from non-randomized drug-drug interaction clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000073 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000073">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Class>
<owl:complementOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:hasValue rdf:resource="http://purl.obolibrary.org/obo/OBI_0302900"/>
</owl:Restriction>
</owl:complementOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0500001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500006"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input, and that does not have group randomization as a part, and that realizes a clinical study design that has parallel group design as a part.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_PK_DDI_Par_Grps</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from parallel groups drug-drug interaction clinical trial'</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000074 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000074">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0302900"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input and does have group randomization as a part.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_PK_DDI_RCT</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from randomized drug-drug interaction clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000075 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000075">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en"></obo:IAO_0000115>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_CT_Pharmacokinetic</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from pharmacokinetic trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000076 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000076">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000750"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in genotyping.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_CT_PK_Genotype</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from genotyped pharmacokinetic trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000077 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000077">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that was triggered by an occurrent.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_Case_Report</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from observation-based report</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000078 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000078">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0300311"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an observation design and has a drug product as a specified input, and that focuses on pharmacokinetics in an organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_PK_Observational</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from observational pharmacokinetic study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000079 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000079">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0300311"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an observation design and has at least two drug products as a specified input, and that focuses on pharmacokinetics in an organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_PK_DDI_Observational</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from observational drug-drug interaction study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000080 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000080">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0000031"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0009892"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input, and that has cell lines as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Recom</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 recombinant drug metabolism inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000081 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000081">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
</owl:Restriction>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0009892"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001479"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000659"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input, and that has human tissue specimens as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome</obo:IAO_0000118>
<obo:IAO_0000119>https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from CYP450 human microsome drug metabolism inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000082 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000082">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000100"/>
<obo:IAO_0000115 xml:lang="en">A data set that is structured and stored on a computer and that is publicly available and contains reports of adverse events.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">public adverse event reporting database</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000083 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000083">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000082"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OAE_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000031"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that was triggered by an adverse drug event, and that is part on a publicly accessible database for adverse event reporting.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_Case_Report_ADE_Public_Reported</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from a publicly reported observation-based adverse drug event report</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000084 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000084">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OAE_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000031"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that was triggered by an adverse drug event following the administration of at least two drugs.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_Case_Report_DI</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from an observation-based case-report of a drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000087 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000087">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000272"/>
<obo:IAO_0000115 xml:lang="en">A protocol that specifies methodology to assess the likelihood of a drug to be the cause for an adverse event by answering a set of questions about the drug reaction report.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">adverse drug reaction causality evaluation protocol</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000088 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000088">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OAE_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000031"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000012"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000013"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000011"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000087"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that was triggered by an adverse drug event following the administration of at least two drugs, and that is the specified outcome of a adverse drug reaction causality evaluation.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_Case_Report_DI_Evaluated</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from an evaluated observation-based case-report of a drug interaction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000089 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000089">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
<obo:IAO_0000115 xml:lang="en">A measurement datum that is the specified output of measuring the volume of plasma that is completely cleared off of a substance per unit time.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Cl</obo:IAO_0000118>
<rdfs:label xml:lang="en">clearance measurement datum</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000091 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000091">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000190"/>
<obo:IAO_0000115 xml:lang="en">A dimensionless ratio unit which describes the relation between the two numbers x and y by giving the multiplier necessary to make x equal to y.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">fold</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000092 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000092">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">An information content entity that is part of a pharmacokinetic parameter ratio and that describes whether the relationship between the numbers of the ratio is a positive or a negative one.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">pharmacokinetic parameter ratio directionality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000093 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000093">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the pharmacokinetic area under the curve (AUC) for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">AUC ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">area under the curve ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000094 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000094">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the measurement of the volume of blood, serum, or plasma from which an active ingredient or a metabolite is completely removed by the kidney in a given amount of time in an organism with and without the inhibiting drug present in the organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en"></obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">CL_R ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">renal clearance ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000095 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000095">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0001938"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115>An information content entity that describes the relationship between the mean (arithmetic and geometric) of measurements of a pharmacokintect parameter for a given drug A in absence of another drug and the mean (arithmetic and geometric) of measurements of a pharmacokintect parameter for a given drug A coadministrated with another drug B.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">pharmacokinetic parameter ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000097 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000097">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000092"/>
<obo:IAO_0000115 xml:lang="en">An pharmacokinetic parameter directionality that describes negative relationship between the numbers of the ratio.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">pharmacokinetic parameter ratio decrease</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000098 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000098">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000092"/>
<obo:IAO_0000115 xml:lang="en">An pharmacokinetic parameter directionality that describes positive relationship between the numbers of the ratio.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">pharmacokinetic parameter ratio increase</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000099 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000099">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the drug maximum concentration measurements for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Cmax ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">drug maximum concentration ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000100 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000100">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the time it takes for half of a given active ingredient or metabolite to be removed from the system of an organism with and without the inhibiting drug present in the organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">t1/2 ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">half-life ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000101 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000101">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the measurement of the volume of blood, serum, or plasma from which an active ingredient or a metabolite is completely removed by the liver in a given amount of time in an organism with and without the inhibiting drug present in the organism.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">CL_H ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">hepatic clearance ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000102 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000102">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the relation between the measurement of the fraction of the administered dose of an unaltered drug that reaches systemic circulation in the abscene of another drug, and the the measurement of the fraction of the administered dose of an unaltered drug that reaches systemic circulation when coadministered with another drug.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">F ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">bioavailability ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000103 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000103">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000052"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ERO_0000923"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in phenotyping.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118>EV_CT_PK_Phenotype</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from phenotyped pharmacokinetic trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000104">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_P_Glycoprotein</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein transport protein identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000105 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000105">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0002172"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein using bidirectional flux in Caco-2 cells.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_P_Glycoprotein_Caco_2</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein transport protein identification experiment using Caco 2 cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000106 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000106">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein using overexpressed cells.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_P_Glycoprotein_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein transport protein identification experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000107 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000107">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015223"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B1.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_OATP1B1</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B1 transport protein identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000108 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000108">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015224"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B3.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_OATP1B3</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B3 transport protein identification experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000109 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000109">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015223"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B1 using overexpressed cells.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_OATP1B1_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B1 transport protein identification experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000110 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000110">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0098739"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015224"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B3 using overexpressed cells.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_ID_OATP1B3_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B3 transport protein identification experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000111 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000111">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_P_Glycoprotein</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000112 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000112">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0002172"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein, and that has Caco 2 cell lines as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_P_Glycoprotein_Caco_2</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein inhibition experiment using Caco 2 cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000113 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000113">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001891"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein, and that has overexpressed cell lines as a specified input.</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_P_Glycoprotein_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from p-glycoprotein inhibition experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000114 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000114">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015223"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B1.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_OATP1B1</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B1 inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000115 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000115">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015223"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B1, and that has overexpressed cell lines as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_OATP1B1_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B1 inhibition experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000116 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000116">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015224"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0000001"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/INO_0000114"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B3, and that has overexpressed cell lines as a specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_OATP1B3_Overexpressed_Cells</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B3 inhibition experiment using overexpressed cell lines</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000117 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000117">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001211"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0032410"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000015224"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B3.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">EV_EX_Trans_Prot_Inhibit_OATP1B3</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from OATP1B3 inhibition experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000118 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000118">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in a bodily fluid for a given active ingredient or metabolite in an organism with and without the inhibiting drug present. It is expressed as a ratio of the volume of distribution with the inhibitor present as the numerator and absent as the denominator.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">amended definition from Spruill WJ, Wade WE, DiPiro JT, Blouin RA, Pruemer JM: Concepts in Clinical Pharmacology. Bethesda, MA, 2014 based on a comment by Philip E. Empey.</obo:IAO_0000119>
<rdfs:label xml:lang="en">volume of distribution ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000119 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000119">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the time from dose administration until a drug reaches its maximum concentration for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism. It is expressed as a ratio of the Tmax with the inhibitor present as the numerator and absent as the denominator.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Tmax ratio</obo:IAO_0000118>
<rdfs:label xml:lang="en">time to maximum drug concentration ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000120 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000120">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the drug transmembrane transporter activity regarding an active ingredient or a metabolite in an in vitro bi-directional transport assay. It is expressed as a ratio of the apparent permeability in the basal to apical direction as the numerator and apparent permeability in the apical-to-basolateral direction as the denominator.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<rdfs:label xml:lang="en">efflux ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000121 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000121">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000095"/>
<obo:IAO_0000115 xml:lang="en">A pharmacokinetic parameter ratio that describes the drug transmembrane transporter activity regarding an active ingredient or a metabolite in an in vitro bi-directional transport assay using transporter transfected cell model. It is expressed as a ratio of the efflux ratio in cells transfected with the transporter as the numerator and efflux ratio in cells not transfected with the transporter (wild type cells) as the denominator.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philip E. Empey</obo:IAO_0000117>
<rdfs:label xml:lang="en">net flux ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000122 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000122">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
<obo:IAO_0000115 xml:lang="en">A measurement data that gives the concentration of an inhibiting agent to reach half of the maximum inhibition of a meabolic or transport process.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">ki</obo:IAO_0000118>
<rdfs:label xml:lang="en">inhibitory constant</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000123 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000123">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">The role that inheres in a chemical substance and that, if realized, is realized by a single, specified metabolic or transport reaction, which is being affected by another chemically substance pharmacokinetically in a drug-drug interaction experiment or natural product-drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">probe subtrate role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000124 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000124">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500001"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<obo:IAO_0000115 xml:lang="en">An assay that is the realization of a concretization of a clinical study design.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">clinical study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000125 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000125">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_1110060"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000020"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 xml:lang="en">A biological process that is the result of a drug-drug interaction.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">drug-drug interaction effect</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000126 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000126">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
<obo:IAO_0000117 xml:lang="en">A value specification that specifies the relationship between two numbers.</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">ratio value specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000127 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000127">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000126"/>
<obo:IAO_0000115 xml:lang="en">A ratio value specification where the relationship between to numbers is expressed as a fraction of 100.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:label xml:lang="en">percentage value specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000128 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000128">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0020000"/>
<obo:IAO_0000115 xml:lang="en">An identifier that denotes a set of drug identifiers.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Term and definition provided by Richard D. Boyce.</rdfs:comment>
<rdfs:label xml:lang="en">drug concept set identifier</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000149 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000149">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell population that is derived from hepatocytes isolated from a human being and that has undergone cryopreservation</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Cells isolated from human liver that have been frozen and stored, usually in liquid nitrogen; an in vitro model system for human metabolism or transport; cells can be thawed and used in metabolism or transport assays</rdfs:comment>
<rdfs:label xml:lang="en">cryopreserved human hepatocyte population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000152 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell population that is derived from hepatocytes freshly isolated from a human being</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Cells isolated from human liver, never frozen; an in vitro model system for human metabolism or transport; cells can be used in metabolism or transport assays</rdfs:comment>
<rdfs:label xml:lang="en">freshly isolated human hepatocyte population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000153 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000153">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell population that is derived from cells isolated from the liver of a transgenic organism</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Cells isolated from livers of transgenic animals; an in vitro model system for human metabolism or transport</rdfs:comment>
<rdfs:label xml:lang="en">transgenic animal hepatocyte population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000154 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000154">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell population derived from hepatocytes, in which, during the culturing process, the cells occupy a region bound by two parallel plates made of gelled collagen</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:label xml:lang="en">sandwich cultured hepatocyte population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000155 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000155">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell population derived from cells isolated from human intestinal epithelium</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:label xml:lang="en">human intestinal epithelial cell population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000157 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000157">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000115 xml:lang="en">an immortal human liver-derived cell line cell that is part of the HepaRG cell line</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">HepaRG cells are terminally differentiated human hepatocellular carcinoma cells that reproducibly express drug-metabolizing enzymes and transporters. They are commonly used for metabolism and transport evaluations in vitro, as they respond and function like primary human hepatocytes across a range of applications.</rdfs:comment>
<rdfs:label xml:lang="en">HepaRG cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000158 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000158">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000115 xml:lang="en">an immortal human liver-derived cell line cell that is part of the Fa2N-4 cell line</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Fa2N-4 cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with Simian virus 40 large T antigen. The donor was tested negative for CMV, HIV, HBV, and HCV. This cell line was mainly used for major CYP induction studies (including CYP3A4/5, 1A2, 2B6, and 2C9) with limitations. Hepatic transporter expression levels are low.</rdfs:comment>
<rdfs:label xml:lang="en">Fa2N-4 cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000159 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000159">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000115 xml:lang="en">an immortal human liver-derived cell line cell that is part of the HBG BC2 cell line</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">BC2 cell</obo:IAO_0000118>
<rdfs:comment xml:lang="en">An Immortalized human hepatoma cell line possesses the capacities of being reversibly differentiated in vitro, and of maintaining a relatviely higher mtabolic rate in the differentiated phase. It is mainly used for repeated toxicity evaluation in vitro.</rdfs:comment>
<rdfs:label xml:lang="en">HBG BC2 cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000160 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000160">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a supernatant role resulting from high-speed centrifugation of a human liver S9 fraction</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Cell cytosol obtained via centrifugation of human liver cells. It is commonly used to support in vitro DMPK studies related to liver cytsolic enzymes, especially non-CYP enzymes, such as phase I enzyme aldehyde oxidase (AO), phase II enzyme SULT.</rdfs:comment>
<rdfs:label xml:lang="en">human liver cytosolic fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000161 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000161">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a supernatant role resulting from high-speed centrifugation of a human intestine S9 fraction</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Cell cytosol obtained via centrifugation of human enterocytes. It is commonly used to support in vitro evaluation of intestinal cytosolic enzymes in the first-pass metabolism of orally ingested xenobitotics.</rdfs:comment>
<rdfs:label xml:lang="en">human intestine cytosolic fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000162 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000162">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a supernatant role resulting from medium-speed centrifugation of a human liver homogenate</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">A mixture of cell cytosol and microsomes isolated by disruption and centrifugation of human liver cells. It contains a wide range of drug-metabolizing enzymes and is commonly used for in vitro DMPK studies, including both phase I and phase II xenobiotic metabolism.</rdfs:comment>
<rdfs:label xml:lang="en">human liver S9 fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000163 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000163">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a human intestine S9 fraction, which is derived from a single donor</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">individual human intestinal microsomes</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Subcellular fractions, derived from endoplasmic reticulum that has been isolated from enterocytes from a single human donor. They contain a rich variety of metaboliz enzymes for assessing first-pass metabolism for orally ingested drugs.</rdfs:comment>
<rdfs:label xml:lang="en">individual human intestinal microsomal fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000164 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000164">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a pool of human liver S9 fractions, which is derived from multiple donors</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">pooled human liver microsomes</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Subcellular fractions, derived from endoplasmic reticulum that has been isolated from liver cells from multiple human donors. They contain a rich variety of metaboliz enzymes (e.g. CYP, UGT, FMO) for assessing drug DMPK in vitro, such as metabolic stability, CYP inhibition, CYP phenotyping, metabolite charaterization, etc.</rdfs:comment>
<rdfs:label xml:lang="en">pooled human liver microsomal fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000165 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000165">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a human liver S9 fraction, which is derived from a single donor</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">individual human liver microsomes</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Subcellular fractions, derived from endoplasmic reticulum that has been isolated from liver cells from a single human donor. They contain a rich variety of metaboliz enzymes (e.g. CYP, UGT, FMO) for assessing drug DMPK in vitro, such as metabolic stability, CYP inhibition, CYP phenotyping, metabolite charaterization, etc.</rdfs:comment>
<rdfs:label xml:lang="en">individual human liver microsomal fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000166 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000166">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a pool of human intestine S9 fractions, which is derived from multiple donors</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">pooled human intestinal microsomes</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Subcellular fractions, derived from endoplasmic reticulum that has been isolated from enterocytes of multiple human donors. They contain a rich variety of metaboliz enzymes for assessing first-pass metabolism for orally ingested drugs.</rdfs:comment>
<rdfs:label xml:lang="en">pooled human intestinal microsomal fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000167 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000167">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000115 xml:lang="en">a processed material that has a supernatant role resulting from medium-speed centrifugation of a human intestine homogenate</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">A mixture of cell cytosol and microsomes isolated by disruption and centrifugation of human enterocytes. It contains a wide range of drug-metabolizing enzymes and is commonly used for in vitro DMPK studies, including both phase I and phase II xenobiotic metabolism.</rdfs:comment>
<rdfs:label xml:lang="en">human intestine S9 fraction</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000168 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000168">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000010"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell that is part of a culture derived from an insect and has a recombinant protein production host role</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">baculovirus-insect cell</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Insect cell-hosted viral system used to produce and express recombinant proteins/enzymes; these systems are used in metabolism studies</rdfs:comment>
<rdfs:label xml:lang="en">baculovirus-insect recombinant protein production host cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000169 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000169">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000010"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_562"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000183"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000010"/>
<obo:IAO_0000115 xml:lang="en">a cultured cell of the species Escherichia coli that bears a recombinant protein production host role</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Prokaryotic in vitro system used to produce and express recombinant proteins/enzymes; these systems are used in metabolism studies</rdfs:comment>
<rdfs:label xml:lang="en">E. coli recombinant protein production host cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000170 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000170">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
<obo:IAO_0000115 xml:lang="en">a measurement datum that describes the decrease in activity of a transporter or enzyme in the presence of a compound from activity in the control experiment</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">% inhibition</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Percent inhibition: the percent decrease in activity of a transporter or enzyme in the presence of a compound from activity in the control experiment</rdfs:comment>
<rdfs:label xml:lang="en">percent inhibition</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000171 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000171">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has midazolam as input and 1'-hydroxymidazolam as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of midazolam at the 1' position to form 1'-hydroxymidazolam;probe substrate of CYP3A4 activity (used to measure CYP3A4 activity)</rdfs:comment>
<rdfs:label xml:lang="en">midazolam 1'-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000172 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000172">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/MOP_0001385"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_34480"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002234"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51602"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0001385"/>
<obo:IAO_0000115 xml:lang="en">a deethylation that has 7-ethoxyresorufin as input and resorufin as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">O-deethylation of 7-Ethoxyresorufin to form resorufin; probe substrate of CYP1A activity</rdfs:comment>
<rdfs:label xml:lang="en">7-ethoxyresorufin O-deethylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000173 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000173">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000590"/>
<obo:IAO_0000115 xml:lang="en">a dehydrogenation that has nifedipine as input and has dehydronifedipine as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Dehydrogenation of nifedipine to dehydronifedipine;probe substrate of CYP3A4 activity (used to measure CYP3A4 activity)</rdfs:comment>
<rdfs:label xml:lang="en">nifedipine dehydrogenation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000174 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000174">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has bufuralol as input and 1'-hydroxybufurolol as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">1'-hydroxylation of bufuralol to form 1'-hydroxybufurolol; probe substrate of CYP2D6 activity</rdfs:comment>
<rdfs:label xml:lang="en">bufuralol 1'-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000175 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000175">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/MOP_0000673"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_7772"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002234"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63840"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has omeprazole as input and has 5-hydroxyomeprazole as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of omeprazole at the 5 position to form 5-hydroxyomeprazole; probe substrate of CYP2C19 activity</rdfs:comment>
<rdfs:label xml:lang="en">omeprazole 5-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000176 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000176">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has bupropion as input and 1-hydroxybupropion as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of bupropion at the 1 position to form 1-hydroxybupropion; probe substrate of CYP2B6 activity</rdfs:comment>
<rdfs:label xml:lang="en">bupropion hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000177 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000177">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has paclitaxel as input and 6-alpha-hydroxypaclitaxel as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of paclitaxel at the 6-alpha position to form 6-alpha-hydroxypaclitaxel; probe substrate of CYP2C8 activity</rdfs:comment>
<rdfs:label xml:lang="en">paclitaxel 6-alpha hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000178 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000178">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0001385"/>
<obo:IAO_0000115 xml:lang="en">a deethylation that has phenacetin as input and acetaminophen as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">O-deethylation of phenacetin to form acetaminophen; probe substrate of CYP1A2 activity</rdfs:comment>
<rdfs:label xml:lang="en">phenacetin O-deethylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000179 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000179">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has coumarin as input and has 7-hydroxycoumarin as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of coumarin at the 7 position to form 7-hydroxycoumarin; probe substrate of CYP2A6 activity</rdfs:comment>
<rdfs:label xml:lang="en">coumarin 7-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000180 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000180">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has testosterone as input and 6-beta-hydroxytestosterone as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of testosterone at the 6-beta position to form 6-beta-hydroxytestosterone; probe substrate of CYP3A4 activity</rdfs:comment>
<rdfs:label xml:lang="en">testosterone 6-beta-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000181 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000181">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/MOP_0001364"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_4470"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002234"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29133"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0001364"/>
<obo:IAO_0000115 xml:lang="en">a demethylation that has dextromethorphan as input and has dextrorphan as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">O-demethylation of dextromethorphan to form dextrorphan;probe substrate of CYP2C9 activity</rdfs:comment>
<rdfs:label xml:lang="en">dextromethorphan O-demethylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000182 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000182">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has diclofenac as input and 4'-hydroxydiclofenac as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of diclofenac to form 4'-hydroxydiclofenac; probe substrate of CYP2C9 activity</rdfs:comment>
<rdfs:label xml:lang="en">diclofenac 4'-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000183 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000183">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000444"/>
<obo:IAO_0000115 xml:lang="en">a target of material addition role that is borne by a cultured cell and, if realized, is realized in recombinant protein production</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">An in vitro system that uses a combination of genetic pieces typically in a plasmid that is incorporated into a host cell which is used to produce the protein of interest</rdfs:comment>
<rdfs:label xml:lang="en">recombinant protein production host role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000184 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000184">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/APOLLO_SV_00000032"/>
<obo:IAO_0000115 xml:lang="en">a count of administrations of a substance to an organism over a duration of 24 hours</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">the frequency of administration of the precipitant during the day</rdfs:comment>
<rdfs:label xml:lang="en">number of doses in a day</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000185 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000185">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0000001"/>
<obo:IAO_0000115 xml:lang="en">an immortal human liver-derived cell line cell that is part of the Hep G2 cell line</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">HepG2 was derived from a liver hepatocellular carcinoma of a 15 year-old Caucasian male. HepG2 cells secrete a variety of major plasma proteins. They are a suitable in vitro model system for the study of polarized human hepatocytes, with high degree of morphological and functional differentiation in vitro. It can be used for hepatic metabolism, transport, and toxicity evaluations in vitro. It was tested negative for HBV.</rdfs:comment>
<rdfs:label xml:lang="en">Hep G2 cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000186 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000186">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0002421"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001152"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0002421"/>
<obo:IAO_0000115 xml:lang="en">a CHO cell that is a specified output of a transfection</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Chinese hamster ovary cells transfected with human transporter DNA; an in vitro model used to study transporters</rdfs:comment>
<rdfs:label xml:lang="en">CHO transfected cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000187 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000187">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000185"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001152"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000185"/>
<obo:IAO_0000115 xml:lang="en">a Hep G2 cell that has a target of material addition role and is a specified input of a transfection</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Well characterized immortalized human liver cancer cell line used as an in vitro model system of metabolism or transport</rdfs:comment>
<rdfs:label xml:lang="en">Hep G2 transfected cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000188 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000188">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0002172"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001148"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ERO_0001209"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0002172"/>
<obo:IAO_0000115 xml:lang="en">a Caco-2 cell that is a specified output of a gene knockout that has specified input siRNA</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Caco-2 cells treated with siRNA designed to down-regulate specific enzymes or transporters</rdfs:comment>
<rdfs:label xml:lang="en">siRNA knockout Caco-2 cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000189 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000189">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0037237"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001152"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0037237"/>
<obo:IAO_0000115 xml:lang="en">a 293-derived cell that is a specified output of a transfection</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">HEK293 transfected cell</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Immortalized human kideny cells transfected/transduced with a transporter or enzyme; an in vitro model overexpressing transporter or enzyme of interest; used for transporter or metabolism assays</rdfs:comment>
<rdfs:label xml:lang="en">293 transfected cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000190 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000190">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/APOLLO_SV_00000032"/>
<obo:IAO_0000115 xml:lang="en">a count of human beings from whom originate hepatocytes to be used in an investigation</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Number of Livers</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Number of individual liver samples used</rdfs:comment>
<rdfs:label xml:lang="en">number of liver donors</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000191 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000191">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/MOP_0000673"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_47381"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002234"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59613"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has diclofenac as input and 4'-hydroxydiclofenac as output</obo:IAO_0000115>
<rdfs:comment xml:lang="en">Hydroxylation of diclofenac to form 4'-hydroxydiclofenac; probe substrate of CYP2C9 activity</rdfs:comment>
<rdfs:label xml:lang="en">diclofenac 4'-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000192 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000192">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has tolbutamide as input and 4-hydroxytolbutamide as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Methyhydroxylation of tolbutamide to form hydroxytolbutamide;probe substrate of CYP2D6 activity</rdfs:comment>
<rdfs:label xml:lang="en">tolbutamide methylhydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000193 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000193">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000156"/>
<obo:IAO_0000115 xml:lang="en">a glucuronosylation that has estradiol as input and has estradiol-3-glucuronide as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Glucuronidation of estradiol to estradiol-3-glucuronide; probe substrate of UGT1A1 activity (used to measure UGT1A1 activity)</rdfs:comment>
<rdfs:label xml:lang="en">estradiol glucuronosylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000194 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000194">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/CLO_0007646"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001152"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CLO_0007646"/>
<obo:IAO_0000115 xml:lang="en">an MDCK cell that is the specified output of a transfection</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Dog cells transfected with human transporter; an in vitro model used to study transporters</rdfs:comment>
<rdfs:label xml:lang="en">MDCK transfected cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000196 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000196">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000156"/>
<obo:IAO_0000115 xml:lang="en">a glucuronosylation that has lamotrigine as input and has lamotrigine glucoronide as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">lamotrigine glucuronidation</obo:IAO_0000118>
<rdfs:comment xml:lang="en">Glucuronidation of lamotrigine; probe substrate of UGT1A4 activity (used to measure UGT1A4 activity)</rdfs:comment>
<rdfs:label xml:lang="en">lamotrigine glucuronosylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00000197 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000197">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000673"/>
<obo:IAO_0000115 xml:lang="en">a hydroxylation that has chlorzoxazone as input and 6-hydroxychlorzoxazone as output</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">John Judkins</obo:IAO_0000117>
<rdfs:comment xml:lang="en">Hydroxylation of chlorzoxazone at the 6 position to form 6-hydroxychlorzoxazone; probe substrate of CYP2E1 activity</rdfs:comment>
<rdfs:label xml:lang="en">chlorzoxazone 6-hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00005000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00005000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a POSITIVE regulation of a metabolic process, as its specified input.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Eric Chou</obo:IAO_0000119>
<obo:IAO_0000119 xml:lang="en">Richard D. Boyce</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from drug metabolism induction experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00005002 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00005002">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the INDUCTION of drug component transporter.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Eric Chou</obo:IAO_0000119>
<obo:IAO_0000119 xml:lang="en">Richard D. Boyce</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from drug transport protein induction experiment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00005004 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00005004">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that has chemical substances as its specific input an that has as its specified output the identification and quantification of chemical constituents</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Eric Chou</obo:IAO_0000119>
<obo:IAO_0000119 xml:lang="en">Richard D. Boyce</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from chemical analytic characterization of material</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DIDEO_00005005 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00005005">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
<obo:IAO_0000115 xml:lang="en">An evidence information content entity that is about an assay that has as its specific input the identity and quantity of chemical constituents of two or more chemical substances, and has is its specified output an assessment of the similarity of the input chemical substances.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Eric Chou</obo:IAO_0000119>
<obo:IAO_0000119 xml:lang="en">Richard D. Boyce</obo:IAO_0000119>
<rdfs:label xml:lang="en">evidence information from chemical analytic metabolomics of material</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DRON_00000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects</obo:IAO_0000115>
<obo:IAO_0000117>William Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<dc:creator>William Hogan</dc:creator>
<rdfs:label xml:lang="en">clinical drug role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DRON_00000005 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000005">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000115 xml:lang="en">a material entity (1) containing at least one scattered molecular aggregate as part (the active ingredient) and (2) that is the bearer of a clinical drug role</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">William Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<dc:creator xml:lang="en">William Hogan</dc:creator>
<rdfs:label xml:lang="en">drug product</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DRON_00000028 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000028">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DRON_00000030"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
<owl:allValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000015"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000031"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000015"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000576"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:allValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111 xml:lang="en">active ingredient role</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">a role of a scattered molecular aggregate that is part of a drug product that is realized by (1) administration of the drug to an organism followed by (2) some change in the structure or functioning of some part of the organism</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">active ingredient</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DRON_00000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000030">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000023"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000576"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 xml:lang="en">role of a scattered molecular aggregate</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">a role borne by a scattered molecular aggregate and realized by its grains participating in one or more processes</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">role of scattered molecular aggregate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DRON_00000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000031">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000090"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OGMS_0000090"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
<obo:IAO_0000111 xml:lang="en">administration of a drug product to an organism</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">William R. Hogan</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">drug administration</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0000630 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000630">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A primer.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reagent that is a polymer comprised of nucleotides, each of which consists of three components: a nitrogenous heterocyclic base, which is either a purine or a pyrimidine; a pentose sugar; and a phosphate group.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melissa Haendel</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://en.wikipedia.org/wiki/Nucleic_acid</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Placeholder for class to be imported from the Reagent Ontology (ReO).</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acid reagent</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0000923 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000923">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization of the phenotype is often done in transgenic or knockout mice.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organismal assay that involves characterization of a phenotype; any observable characteristic or trait of an organism: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest). Phenotypes result from the expression of an organism's genes as well as the influence of environmental factors and the interactions between the two.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Nicole Vasilevsky</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://en.wikipedia.org/wiki/Phenotype</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">phenotype characterization</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0001202 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0001202">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000630"/>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A riboprobe.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A reagent that is a polymer comprised of RNA nucleotides.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Placeholder for class to be imported from the Reagent Ontology (ReO).</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNA reagent</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0001205 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0001205">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0001202"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An RNA reagent consisting of a short, linear RNA polymer, typically with 100 or fewer bases.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000117>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNA oligo</obo:IAO_0000118>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Placeholder for class to be imported from the Reagent Ontology (ReO).</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNA oligonucleotide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0001206 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0001206">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0001205"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An RNA interference reagent used to silence expression of a target gene in cells, through the RNA interference pathway.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000117>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNAi oligonucleotide</obo:IAO_0000118>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Placeholder for class to be imported from the Reagent Ontology (ReO).</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RNA interference oligonucleotide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/ERO_0001209 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0001209">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0001206"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An RNA interference oligonucleotide capable of silencing expression of a target gene through the RNAi pathway. siRNAs are synthesized as single-stranded molecules, typically 19-25 nucleotides in length, and paired with complementary sequences to form duplexes that serve as substrates for cellular RNAi processing machinery.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000117>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">siRNA oligo</obo:IAO_0000118>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MHB, http://www.sigmaaldrich.com/life-science/custom-oligos/sirna-oligos.html</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Placeholder for class to be imported from the Reagent Ontology (ReO).</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">siRNA oligonucleotide</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/FMA_62970 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/FMA_62970">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/FMA_9669"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Body substance in liquid state contained in the lumen of arterial and venous trees, blood capillary and the cardiac chambers; constitutes the liquid phase of blood.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/fma.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blood plasma</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fma</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FMA:62970</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Portion of plasma</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/FMA_9669 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/FMA_9669">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Material anatomical entity in a gaseous, liquid, semisolid or solid state, with or without the admixture of cells and biological macromolecules; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures. Examples: saliva, semen, cerebrospinal fluid, respiratory air, urine, feces, blood, plasma, lymph.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/fma.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Body substance</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fma</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FMA:9669</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Portion of body substance</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0003674 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003674">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000060"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/obo/owl/go_xp_all</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0005554</oboInOwl:hasAlternativeId>
<oboInOwl:hasDefinition>
<rdf:Description/>
</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>
<rdf:Description/>
</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular function</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym>
<rdf:Description/>
</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular_function</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0003674</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_candida"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_goa"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_yeast"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#gosubset_prok"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.</rdfs:comment>
<rdfs:label xml:lang="en">molecular_function</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular_function</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0003824 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003824">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/obo/owl/go_xp_all</obo:IAO_0000412>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Enzyme</oboInOwl:hasDbXref>
<oboInOwl:hasDefinition>
<rdf:Description/>
</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>
<rdf:Description/>
</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">enzyme activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular_function</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0003824</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_goa"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#gosubset_prok"/>
<rdfs:label xml:lang="en">catalytic activity</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">catalytic activity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0005575 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0005575">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0008372</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NIF_Subcellular:sao-1337158144</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NIF_Subcellular:sao1337158144</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell or subcellular entity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular component</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">subcellular entity</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0005575</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0006810 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0006810">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051234"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0015457</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0015460</oboInOwl:hasAlternativeId>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">small molecule transport</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute:solute exchange</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">auxiliary transport protein activity</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">transport accessory protein activity</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0006810</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">transport</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0008150 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</obo:IAO_0000111>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0008152 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Metabolism</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolism</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolic process resulting in cell growth</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolism resulting in cell growth</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0008152</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">metabolic process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0009892 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009892">
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0065007"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0008152"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0065007"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down regulation of metabolic process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down-regulation of metabolic process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">downregulation of metabolic process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of metabolism</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibition of metabolic process</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0009892</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of metabolic process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0009987 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009987">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/obo/owl/go_xp_all</obo:IAO_0000412>
<oboInOwl:hasAlternativeId>GO:0008151</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId>GO:0050875</oboInOwl:hasAlternativeId>
<oboInOwl:hasDefinition>
<rdf:Description/>
</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>
<rdf:Description/>
</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>
<rdf:Description/>
</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym>
<rdf:Description/>
</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_goa"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_plant"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#gosubset_prok"/>
<rdfs:label xml:lang="en">cellular process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0017144 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0017144">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008152"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/obo/owl/go_xp_all</obo:IAO_0000412>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>
<rdf:Description/>
</oboInOwl:hasDbXref>
<oboInOwl:hasDefinition>
<rdf:Description/>
</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>
<rdf:Description/>
</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.org/obo/owl/obo#gosubset_prok"/>
<rdfs:label xml:lang="en">drug metabolic process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0019814 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0019814">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0043234"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0019814</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">immunoglobulin complex</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0032409 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032409">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051049"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that modulates the activity of a transporter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0032409</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of transporter activity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0032410 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032410">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032409"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that stops or reduces the activity of a transporter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down regulation of transporter activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down-regulation of transporter activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">downregulation of transporter activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibition of transporter activity</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0032410</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of transporter activity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0032879 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032879">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050789"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of localisation</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0032879</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of localization</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0032991 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032991">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecule complex</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0032991</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecular complex</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0042571 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0042571">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0019814"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Antibody</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">antibody</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0042571</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">immunoglobulin complex, circulating</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0043234 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0043234">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032991"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Protein_complex</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein-protein complex</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular_component</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0043234</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein complex</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0044237 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0044237">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008152"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The chemical reactions and pathways by which individual cells transform chemical substances.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular metabolism</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">intermediary metabolism</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0044237</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cellular metabolic process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0048518 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048518">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050789"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0043119</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">positive regulation of physiological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">up regulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">up-regulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">upregulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">activation of biological process</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">stimulation of biological process</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0048518</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">positive regulation of biological process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0048519 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048519">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050789"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0043118</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down regulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down-regulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">downregulation of biological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of physiological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibition of biological process</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0048519</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of biological process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0050789 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050789">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0065007"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0050791</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of physiological process</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0050789</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of biological process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0051049 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051049">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032879"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0051049</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation of transport</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0051051 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051051">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051049"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down regulation of transport</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">down-regulation of transport</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">downregulation of transport</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibition of transport</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0051051</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">negative regulation of transport</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0051179 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051179">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment and maintenance of localization</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment and maintenance of position</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">localisation</oboInOwl:hasExactSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment and maintenance of cellular component location</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment and maintenance of substance location</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasNarrowSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment and maintenance of substrate location</oboInOwl:hasNarrowSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0051179</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">localization</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0051234 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051234">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment of localisation</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0051234</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">establishment of localization</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0065007 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0065007">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process that modulates a measurable attribute of any biological process, quality or function.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulation</oboInOwl:hasBroadSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0065007</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gosubset_prok"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological regulation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0098657 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0098657">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0006810"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uptake</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0098657</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">import into cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/GO_0098739 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0098739">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0098657"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/go.owl</obo:IAO_0000412>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GO:0098739</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">import across plasma membrane</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/IAO_0000027 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000027"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000030"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000032 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000032"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000033 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000033"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000100 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000100"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000104"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000109 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000109"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000310 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000310"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000311 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000311"/>
<!-- http://purl.obolibrary.org/obo/IAO_0020000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0020000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 xml:lang="en">An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.</obo:IAO_0000115>
<obo:IAO_0000117>Mathias Brochhausen</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">proper name</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/apollo_sv/v4.1.1./apollo_sv.owl</obo:IAO_0000412>
<apollo_sv:APOLLO_SV_0000040 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">name</apollo_sv:APOLLO_SV_0000040>
<dc:creator>Mathias Brochhausen</dc:creator>
<rdfs:comment xml:lang="en">Sep 29, 2016: The current definition has been amended from the previous version: "A proper name is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity." to more accuratly reflect the necessary and sufficient condition on the class. (MB)</rdfs:comment>
<rdfs:label xml:lang="en">identifier</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/IDO_0100872 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/IDO_0100872">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000115>A role that inheres in a protein or a compound upon which enzyme catalyzes. It is realized in the enzymatic reaction processes, where the molecules at the beginning of the process, called substrates, are converted into different molecules, called products.</obo:IAO_0000115>
<rdfs:label>enzyme substrate role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/INO_0000102 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/INO_0000102">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
<obo:IAO_0000115>a biological interaction that uses the information from a gene to synthesize a functional gene product. </obo:IAO_0000115>
<obo:IAO_0000117>YH, ZX</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/in/ino.owl</obo:IAO_0000412>
<obo:INO_0000006>express, expressed, expresses, expressing, expression, expressions</obo:INO_0000006>
<rdfs:label>gene expression</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/INO_0000114 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/INO_0000114">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/INO_0000102"/>
<obo:IAO_0000115>a gene expression that has increased volume. </obo:IAO_0000115>
<obo:IAO_0000117>YH, ZX</obo:IAO_0000117>
<obo:IAO_0000118>increased gene expression</obo:IAO_0000118>
<obo:IAO_0000118>overexpression</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/in/ino.owl</obo:IAO_0000412>
<obo:INO_0000006>hyper-expression, hyperactivate, hyperactivated, hyperactivates, hyperactivation, hyperexpression, overexpression</obo:INO_0000006>
<rdfs:label>overexpression</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000156 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000156">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000779"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Formation of a covalent bond between a substrate and a glucuronosyl group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glucuronosylation</oboInOwl:hasExactSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000156</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_participant: CHEBI:24303</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glucuronosylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000543 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000543">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A process in which at least one of the participants is a molecule.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000543</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TODO: needs work, formal definition, etc.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000590 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000590">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An oxidation process that involves the removal of adjacent hydrogen atoms, resulting in an increase of bond order.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">batchelorc</oboInOwl:created_by>
<oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009-06-05T04:54:48Z</oboInOwl:creation_date>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000590</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dehydrogenation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000673 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000673">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000779"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Formation of a covalent bond between a substrate and a hydroxy group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000673</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hydroxylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000779 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000779">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000543"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000779</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">formation of covalent bond</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0000780 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0000780">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000543"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0000780</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">breaking of covalent bond</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0001364 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0001364">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000780"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Breaking of a covalent bond between a substrate and a methyl group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0001364</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_participant: CHEBI:32875</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">demethylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/MOP_0001385 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/MOP_0001385">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MOP_0000780"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Breaking of a covalent bond between a substrate and an ethyl group.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/mop.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">de-ethylation</oboInOwl:hasExactSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MOP:0001385</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_participant: CHEBI:37807</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">deethylation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCBITaxon_451864 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_451864">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/doid.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dikarya</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCBITaxon_562 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_562">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/vo.owl</obo:IAO_0000412>
<obo:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NCBITaxon:1637691</obo:hasAlternativeId>
<obo:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NCBITaxon:662101</obo:hasAlternativeId>
<obo:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NCBITaxon:662104</obo:hasAlternativeId>
<obo:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GC_ID:11</obo:hasDbXref>
<obo:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:10319482</obo:hasDbXref>
<obo:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">E. coli</obo:hasExactSynonym>
<obo:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Escherichia/Shigella coli</obo:hasExactSynonym>
<obo:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ncbi_taxonomy</obo:hasOBONamespace>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bacillus coli</obo:hasRelatedSynonym>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bacterium coli</obo:hasRelatedSynonym>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bacterium coli commune</obo:hasRelatedSynonym>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Enterococcus coli</obo:hasRelatedSynonym>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Escherchia coli</obo:hasRelatedSynonym>
<obo:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eschericia coli</obo:hasRelatedSynonym>
<ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_species"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Escherichia coli</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCBITaxon_8355 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_8355">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">African clawed frog</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bufo laevis</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xenopus laevis (Daudin, 1802)</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xenopus leavis</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">clawed frog</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">common platanna</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">platanna</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ero.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xenopus laevis</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homo sapiens</obo:IAO_0000111>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human being</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">man</obo:IAO_0000118>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homo sapiens</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OAE_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000061"/>
<obo:IAO_0000115>a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.</obo:IAO_0000115>
<rdfs:label xml:lang="en">adverse event</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OAE_0000005 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000005">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OAE_0000001"/>
<obo:IAO_0000115>an adverse event that occurs after a drug administration</obo:IAO_0000115>
<rdfs:label xml:lang="en">adverse drug event</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OAE_0000055 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000055">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
<obo:IAO_0000115 xml:lang="en">A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment.</obo:IAO_0000115>
<obo:IAO_0000119>http://en.wikipedia.org/wiki/Contraindication</obo:IAO_0000119>
<rdfs:label xml:lang="en">contraindication</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OAE_0000095 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000095">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OAE_0000005"/>
<obo:IAO_0000115>a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event.</obo:IAO_0000115>
<rdfs:label xml:lang="en">causal adverse drug event</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OAE_0000631 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000631">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OAE_0000001"/>
<obo:IAO_0000115>serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death.</obo:IAO_0000115>
<rdfs:label>severe adverse event</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000011 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000011">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000001"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000029 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000029">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 xml:lang="en">centrifuge pellet role</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Definition of pellet :the material concentrated at the bottom of a centrifuge tube after centrifugation. http://www.everythingbio.com/glos/definition.php?word=pellet</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">pellet role is a role which inheres in a material entity and is realized by a material separation process using gravitational force generated by a centrifuge in which the material bearing the pellet role is the heavier or heaviest component of the output material..</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role branch</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
<obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9Mar09 after discussion with process branch changed definition to include use of centrifuge;</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">centrifuge pellet role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000034 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000034">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 xml:lang="en">supernatant role</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Precipitation is the formation of a solid in a solution during a chemical reaction. When the reaction occurs, the solid formed is called the precipitate, and the liquid remaining above the solid is called the supernate. Wikipedia</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role branch</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">supernatant role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000047 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000047">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000111 xml:lang="en">processed material</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">Is a material entity that is created or changed during material processing.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">processed material</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000067 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000067">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 xml:lang="en">evaluant role</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is)</obo:IAO_0000116>
<obo:IAO_0000116 xml:lang="en">examples of features that could be described in an evaluant: quality.... e.g. "contains 10 pg/ml IL2", or "no glucose detected")</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role Branch</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
<obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">evaluant role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000070 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000070">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000111 xml:lang="en">assay</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.</obo:IAO_0000115>
<obo:IAO_0000116>12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation. </obo:IAO_0000116>
<obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">measuring</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">scientific observation</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study assay</obo:OBI_0001847>
<obo:OBI_9991118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">any method</obo:OBI_9991118>
<rdfs:label xml:lang="en">assay</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000094 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000094">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000111 xml:lang="en">material processing</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell lysis, production of a cloning vector, creating a buffer.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A planned process which results in physical changes in a specified input material</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Frank Gibson</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Jennifer Fostel</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca Serra</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">material transformation</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">material processing</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000192 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000192">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000967"/>
<obo:IAO_0000111 xml:lang="en">microtiter plate</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">A microtiter plate with 6, 24, 96, 384 or 1536 sample wells used in the enzyme-linked immunosorbent assay (ELISA)</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A microtiter_plate is a flat plate with multiple wells used as small test tubes.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Melanie Courtot</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">microplate</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">http://en.wikipedia.org/wiki/Microtiter_plate</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">microtiter plate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000272 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000272">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
<obo:IAO_0000111 xml:lang="en">protocol</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study protocol</obo:OBI_0001847>
<rdfs:label xml:lang="en">protocol</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000427 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000427">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000111 xml:lang="en">enzyme</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">(protein or rna) or has_part (protein or rna) and
has_function some GO:0003824 (catalytic activity)</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MC: known issue: enzyme doesn't classify under material entity for now as it isn't stated that anything
that has_part some material entity is a material entity. If we add as equivalent classes to material entity has_part some material entity and part_of some material entity (each one in his own necessary and sufficient block) Pellet in P3 doesn't classify any more.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">person: Melanie Courtot</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP:OBI</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">enzyme</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000444 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000444">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 xml:lang="en">target of material addition role</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peritoneum of an animal receiving an interperitoneal injection; solution in a tube receiving additional material; location of absorbed material following a dermal application.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">target of material addition role is a role realized by an entity into which a material is added in a material addition process</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">From Branch discussion with BP, AR, MC -- there is a need for the recipient to interact with the administered material. for example, a tooth receiving a filling was not considered to be a target role.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role Branch</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">target of material addition role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000571 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000571">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">manufacturer role</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">With respect to The Accuri C6 Flow Cytometer System, the organization Accuri bears the role manufacturer role. With respect to a transformed line of tissue culture cells derived by a specific lab, the lab whose personnel isolated the cll line bears the role manufacturer role. With respect to a specific antibody produced by an individual scientist, the scientist who purifies, characterizes and distributes the anitbody bears the role manufacturer role.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role Branch</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">manufacturer role</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000576 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000576">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000027"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">scattered molecular aggregate</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the sodium and chloride ions in a glass of salt water</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 xml:lang="en">A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">Collective</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">scattered molecular aggregate</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000659 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000659">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection process</obo:IAO_0000111>
<obo:IAO_0000112>drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A planned process with the objective of collecting a specimen.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.</obo:IAO_0000116>
<obo:IAO_0000116>Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role.</obo:IAO_0000116>
<obo:IAO_0000116>Philly2013: The specimen_role for the specimen is created during the specimen collection process.</obo:IAO_0000116>
<obo:IAO_0000116>label changed to 'specimen collection process' on 10/27/2014, details see tracker:
http://sourceforge.net/p/obi/obi-terms/716/</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000118>specimen collection</obo:IAO_0000118>
<obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession</obo:IAO_0000232>
<obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6/9/09: used at workshop</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000967 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000967">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000968"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">container</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A device that can be used to restrict the location of material entities over time</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">03/21/2010: Added to allow classification of children (similar to what we want to do for 'measurement device'. Lookint at what classifies here, we may want to reconsider a contain function assigned to a part of an entity is necessarily also a function of the whole (e.g. is a centrifuge a container because it has test tubes as parts?)</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">container</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000968 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000968">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">device</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A voltmeter is a measurement device which is intended to perform some measure function.</obo:IAO_0000112>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material entity that is designed to perform a function in a scientific investigation, but is not a reagent.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of "device", and are enumerating the types of roles that a reagent can perform.
2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example:
(1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part.
(2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay.
(3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel.
In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay. </obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Helen Parkinson</obo:IAO_0000117>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">instrument</obo:IAO_0000118>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI development call 2012-12-17.</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">device</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0000969 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000969">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose specification</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a protocol specifying to administer 1 ml of vaccine to a mouse</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a directive information entity that describes the dose that will be administered to a target</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001148 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001148">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600043"/>
<obo:IAO_0000111 xml:lang="en">gene knock out</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">a genetic transformation that renders a gene non-functional, e.g. due to a point mutation, or the removal of all, or part of, the gene using recombinant methods.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">MO_771 gene_knock_out</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">gene knock out</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001152 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600043"/>
<obo:IAO_0000111 xml:lang="en">transfection</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">a genetic transformation which relies on the use of physical, electrical and chemical phenomena to introduce DNA or RNA into a cell</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MO_366 transfection</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">transfection</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001180 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001180">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">half maximal effective concentration (EC50)</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Determining the potentency of a drug / antibody / toxicant by measuring a graded dose response curve, and determining the concentration of the compound where 50% of its maximal effect is observed. </obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">half maximal effective concentration (EC50) is a scalar measurement datum corresponding to the concentration of a compound which induces a response halfway between the baseline and maximum after some specified exposure time.
</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters; Randi Vita</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">wikipedia</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">half maximal effective concentration (EC50)</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001191 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001191">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">half maximal inhibitory concentration (IC50)</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interpolating that at a dose of IC50=12 nM, half of the binding of a comptetitive ligand is inhibited.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Half maximal inhibitory concentration (IC50) is a scalar measurement datum that measures the effectiveness of a compound to competitively inhibit a given process, and corresponds to the concentration of the compound at which it reaches half of its maximum inhibitory effect.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters; Randi Vita</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">wikipedia</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">half maximal inhibitory concentration (IC50)</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001211 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001211">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111 xml:lang="en">ex vivo design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design where all or part of an organism is removed and studied in vitro, e.g. part of a mouse is removed and cultured in vitro. A cell culture with an established cell line is an in vitro experiment.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">MO_808 ex_vivo_design</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">ex vivo design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001285 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001285">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111 xml:lang="en">in vitro design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that is done in a test tube or a culture dish, e.g. A bacterial invasion assay in an established cell culture.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">MO_347 in_vitro_design</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">in vitro design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001479 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001479">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100051"/>
<obo:IAO_0000111 xml:lang="en">tissue specimen</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm).</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MO_954 organism_part</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">tissue specimen</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001929 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001929">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001931"/>
<obo:IAO_0000111>mass value specification</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115>A value specification that specifies the mass of some thing.</obo:IAO_0000115>
<obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label>mass value specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001931 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001931">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
<obo:IAO_0000111>scalar value specification</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115>A value specification that consists of two parts: a numeral and a unit label</obo:IAO_0000115>
<obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label>scalar value specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001933 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001933">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000111>value specification</obo:IAO_0000111>
<obo:IAO_0000112>The value of 'positive' in a classification scheme of "positive or negative"; the value of '20g' on the quantitative scale of mass.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115>An information content entity that specifies a value within a classification scheme or on a quantitative scale.</obo:IAO_0000115>
<obo:IAO_0000116>This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement.</obo:IAO_0000116>
<obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label>value specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0100026 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100026">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000111 xml:lang="en">organism</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">animal</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">fungus</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">plant</obo:IAO_0000112>
<obo:IAO_0000112 xml:lang="en">virus</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')</obo:IAO_0000116>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">13-02-2009:
OBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus.
This issue is outside the scope of OBI.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI Biomaterial Branch</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">WEB: http://en.wikipedia.org/wiki/Organism</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0100051 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100051">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000111 xml:lang="en">specimen</obo:IAO_0000111>
<obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">A material entity that has the specimen role.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">GROUP: OBI Biomaterial Branch</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">specimen</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0100060 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100060">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell population</obo:IAO_0000111>
<obo:IAO_0000112>A cultured cell population applied in an experiment: "293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest." (Lee, Ramee, et al. "Regulation of cell survival by secreted proneurotrophins." Science 294.5548 (2001): 1945-1948).
A cultured cell population maintained in vitro: "Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks" (Dichter, Marc A. "Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation." Brain Research 149.2 (1978): 279-293).</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history.</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">2013-6-5 MHB: This OBI class was formerly called 'cell culture', but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Matthew Brush</obo:IAO_0000117>
<obo:IAO_0000118>cell culture sample</obo:IAO_0000118>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Matthew Brush</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The extent of a 'cultured cell population' is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0300311 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0300311">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111 xml:lang="en">observation design</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">PMID: 12387964.Lancet. 2002 Oct 12;360(9340):1144-9.Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">observation design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0302886 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0302886">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600014"/>
<obo:IAO_0000111 xml:lang="en">centrifugation</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">PMID: 18428461.Purification of oligodendrocytes and their progenitors using immunomagnetic separation and Percoll gradient centrifugation. Curr Protoc Neurosci. 2001 May;Chapter 3:Unit 3.12.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">centrifugation is a process separating molecules by size or density using centrifugal forces generated by a spinning rotor. G-forces of several hundred thousand times gravity are generated in ultracentrifugation</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adapted from http://www.fao.org/DOCREP/003/X3910E/X3910E06.htm</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">centrifugation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0302900 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0302900">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600015"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0500000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
<obo:IAO_0000111 xml:lang="en">study design</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution.</obo:IAO_0000115>
<obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available.</obo:IAO_0000116>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Chris Stoeckert</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">experimental design</obo:IAO_0000118>
<obo:IAO_0000232 xml:lang="en">rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol.</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">study design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0500001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111 xml:lang="en">clinical study design</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">PMID: 17655677.J Cardiovasc Electrophysiol. 2007 Aug;18(9):965-71.Biventricular versus right ventricular pacing in patients with AV block (BLOCK HF): clinical study design and rationale.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">Plan for the precise procedure to be followed in a clinical trial, including planned and actual timing of events, choice of control group, method of allocating treatments, blinding methods; assigns a subject to pass through one or more epochs in the course of a trial. Specific design elements, e.g., crossover, parallel; dose-escalation [Modified from Pocock, Clinical Trials: A Practical Approach]</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">The definition needs to be extended to other things than simply patients</obo:IAO_0000116>
<obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">Clinical Research Glossary Version 4.0 CDICS glossary group</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">clinical study design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0500006 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500006">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111 xml:lang="en">parallel group design</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">PMID: 17408389-Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron((R)) as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">A parallel group design or independent measure design is a study design which uses unique experimental unit each experimental group, in other word no two individuals are shared between experimental groups, hence also known as parallel group design. Subjects of a treatment group receive a unique combination of independent variable values making up a treatment</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">independent measure design</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">http://www.holah.karoo.net/experimentaldesigns.htm</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">parallel group design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0600014 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600014">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
<obo:IAO_0000111 xml:lang="en">material component separation</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">a material processing in which components of an input material become segregated in space</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">IEDB</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">material component separation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0600015 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600015">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000111 xml:lang="en">group assignment</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">Assigning' to be treated with active ingredient role' to an organism during group assignment. The group is those organisms that have the same role in the context of an investigation</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">group assignment is a process which has an organism as specified input and during which a role is assigned</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cohort assignment</obo:IAO_0000118>
<obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study assignment</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">OBI Plan</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">group assignment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0600043 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600043">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
<obo:IAO_0000111 xml:lang="en">genetic transformation</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">The transduction of E. coli through the introduction of a plasmid encoding for M. avium p35</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115 xml:lang="en">the introduction. alteration or integration of genetic material into a cell or organism</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON:Kevin Clancy</obo:IAO_0000117>
<obo:IAO_0000118 xml:lang="en">genetic modification</obo:IAO_0000118>
<obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">genetic transformation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_1000024 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_1000024">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
<obo:IAO_0000111 xml:lang="en">cell pellet</obo:IAO_0000111>
<obo:IAO_0000112 xml:lang="en">Detection of fetal DNA in a cell pellet after centrifugation of mountant. J Forensic Sci. 2003 Jan;48(1):135-6. PMID: 12570214</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A material entity which results from the aggregation of cells produced by the application of centrifugal force to a liquid containing cells in suspension</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">PERSON: Helen Parkinson</obo:IAO_0000117>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">GROUP: CEBS</obo:IAO_0000119>
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI Biomaterial Branch</obo:IAO_0000119>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<rdfs:label xml:lang="en">cell pellet</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OGMS_0000060 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OGMS_0000060">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
<obo:IAO_0000117>Albert Goldfain</obo:IAO_0000117>
<obo:IAO_0000232>creation date: 2009-06-23T11:53:49Z</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ogms.owl</obo:IAO_0000412>
<rdfs:label>bodily process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OGMS_0000061 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OGMS_0000061">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000060"/>
<obo:IAO_0000115 xml:lang="en">A bodily process that is clinically abnormal.</obo:IAO_0000115>
<obo:IAO_0000117>Albert Goldfain</obo:IAO_0000117>
<obo:IAO_0000119>http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf</obo:IAO_0000119>
<obo:IAO_0000232>creation date: 2009-06-23T11:54:29Z</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/ogms.owl</obo:IAO_0000412>
<rdfs:label>pathological bodily process</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OGMS_0000090 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OGMS_0000090">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
<obo:IAO_0000115 xml:lang="en">A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder</obo:IAO_0000115>
<obo:IAO_0000117>Albert Goldfain</obo:IAO_0000117>
<obo:IAO_0000119>http://code.google.com/p/ogms/issues/detail?id=35</obo:IAO_0000119>
<obo:IAO_0000232>creation date: 2010-03-31T04:51:11Z</obo:IAO_0000232>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/dron.owl</obo:IAO_0000412>
<rdfs:label>treatment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PR_000001891 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000001891">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<obo:IAO_0000111 xml:lang="en">p-glycoprotein</obo:IAO_0000111>
<rdfs:label xml:lang="en">multidrug resistance protein 1</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PR_000013030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000013030">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A protein that is a translation product of the human POR gene or a 1:1 ortholog thereof.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/pr.owl</obo:IAO_0000412>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">P450R</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">POR</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CPR</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CYPOR</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PR:000013030</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Category=gene.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH--cytochrome P450 reductase</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PR_000015223 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000015223">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A solute carrier organic anion transporter family member that is a translation product of the human SLCO1B1 gene or a 1:1 ortholog thereof.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/pr/pr-non-classified.owl</obo:IAO_0000412>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LST-1</oboInOwl:hasBroadSynonym>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">liver-specific organic anion transporter 1</oboInOwl:hasBroadSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATP-2</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATP-C</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLCO1B1</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute carrier family 21 member 6</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LST1</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATP2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATPC</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLC21A6</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sodium-independent organic anion-transporting polypeptide 2</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PR:000015223</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Category=gene.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute carrier organic anion transporter family member 1B1</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PR_000015224 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000015224">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A solute carrier organic anion transporter family member that is a translation product of the human SLCO1B3 gene or a 1:1 ortholog thereof.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/pr/pr-non-classified.owl</obo:IAO_0000412>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PR:000015969</oboInOwl:hasAlternativeId>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LST-1</oboInOwl:hasBroadSynonym>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">liver-specific organic anion transporter 1</oboInOwl:hasBroadSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LST-2</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATP-8</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLC21A6</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLCO1B3</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">liver-specific organic anion transporter 2</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic anion transporter 8</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic anion-transporting polypeptide 8</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute carrier family 21 member 10</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute carrier family 21 member 8</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LST2</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OATP8</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLC21A8</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Slc21a10</oboInOwl:hasRelatedSynonym>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Slco1b2</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PR:000015224</oboInOwl:id>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Category=gene.</rdfs:comment>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">solute carrier organic anion transporter family member 1B3</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/STATO_0000209 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/STATO_0000209">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
<obo:IAO_0000112 xml:lang="en">PMID:12892658 "Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change."</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">Area under curve is a measurement datum which corresponds to the surface define by the x-axis and bound by the line graph represented in a 2 dimensional plot resulting from an integration or integrative calculus. The interpretation of this measurement datum depends on the variables plotted in the graph</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">PRS: submit 'integral calculus' as a kind of data transformation in OBI:DT branch</obo:IAO_0000116>
<obo:IAO_0000117 xml:lang="en">Orlaith Burke, Philippe Rocca-Serra, Alejandra Gonzalez-Beltran</obo:IAO_0000117>
<rdfs:label xml:lang="en">area under curve</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UBERON_0000465 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000465">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anatomical entity that has mass.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uberon.owl</obo:IAO_0000412>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AAO:0010264</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AEO:0000006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BILA:0000006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CARO:0000006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EHDAA2:0003006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FBbt:00007016</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FMA:67165</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HAO:0000006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TAO:0001836</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TGMA:0001826</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VHOG:0001721</oboInOwl:hasDbXref>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uberon</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UBERON:0000465</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material anatomical entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UBERON_0000467 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000467">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uberon.owl</obo:IAO_0000412>
<oboInOwl:hasBroadSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">system</oboInOwl:hasBroadSynonym>
<oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Organ_system"/>
<oboInOwl:hasDbXref rdf:resource="http://linkedlifedata.com/resource/umls/id/C0460002"/>
<oboInOwl:hasDbXref rdf:resource="http://ncicb.nci.nih.gov/xml/owl/EVS/Organ_System"/>
<oboInOwl:hasDbXref rdf:resource="http://uri.neuinfo.org/nif/nifstd/birnlex_14"/>
<oboInOwl:hasDbXref rdf:resource="http://www.snomedbrowser.com/Codes/Details/278195005"/>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AAO:0000007</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AEO:0000011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BILA:0000011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BSA:0000049</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CALOHA:TS-2088</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CARO:0000011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EHDAA2:0003011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EHDAA:392</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EMAPA:16103</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EV:0100000</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FBbt:00004856</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FMA:7149</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HAO:0000011</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MA:0000003</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TAO:0001439</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TGMA:0001831</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0460002</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VHOG:0001725</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WBbt:0005746</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WBbt:0005763</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">XAO:0003002</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ZFA:0001439</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">galen:AnatomicalSystem</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">body system</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">connected anatomical system</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organ system</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uberon</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">anatomical systems</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UBERON:0000467</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#pheno_slim"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#uberon_slim"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">anatomical system</rdfs:label>
<rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/EHDAA2_0001330"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UBERON_0001007 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001007">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000467"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://www.ebi.ac.uk/efo/efo.owl</obo:IAO_0000412>
<obo:UBPROP_0000001 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]</obo:UBPROP_0000001>
<obo:UBPROP_0000007 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">digestive</obo:UBPROP_0000007>
<efo:AAO_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AAO:0000129</efo:AAO_definition_citation>
<efo:BILA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BILA:0000082</efo:BILA_definition_citation>
<efo:BTO_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BTO:0000058</efo:BTO_definition_citation>
<efo:CALOHA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CALOHA:TS-1293</efo:CALOHA_definition_citation>
<efo:EFO_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EFO:0000793</efo:EFO_definition_citation>
<efo:EV_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EV:0100056</efo:EV_definition_citation>
<efo:FBbt_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FBbt:00005055</efo:FBbt_definition_citation>
<efo:FMA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FMA:7152</efo:FMA_definition_citation>
<efo:GAID_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GAID:278</efo:GAID_definition_citation>
<efo:MAT_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MAT:0000018</efo:MAT_definition_citation>
<efo:MA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MA:0002431</efo:MA_definition_citation>
<efo:MESH_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MESH:A03</efo:MESH_definition_citation>
<efo:MIAA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MIAA:0000018</efo:MIAA_definition_citation>
<efo:NCI_Thesaurus_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NCI_Thesaurus:Digestive_System</efo:NCI_Thesaurus_definition_citation>
<efo:SNOMEDCT_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT:278859004</efo:SNOMEDCT_definition_citation>
<efo:TADS_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TADS:0000170</efo:TADS_definition_citation>
<efo:TAO_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TAO:0000339</efo:TAO_definition_citation>
<efo:WBbt_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WBbt:0005748</efo:WBbt_definition_citation>
<efo:Wikipedia_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wikipedia:Digestive_system</efo:Wikipedia_definition_citation>
<efo:XAO_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">XAO:0000125</efo:XAO_definition_citation>
<efo:ZFA_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ZFA:0000339</efo:ZFA_definition_citation>
<efo:alternative_term rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alimentary system</efo:alternative_term>
<efo:alternative_term rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alimentary tract</efo:alternative_term>
<efo:alternative_term rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gastrointestinal system</efo:alternative_term>
<efo:alternative_term rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gut</efo:alternative_term>
<efo:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.</efo:definition>
<efo:galen_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">galen:DigestiveSystem</efo:galen_definition_citation>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uberon</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UBERON:0001007</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon#efo_slim"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon#uberon_slim"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon#vertebrate_core"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">digestive system</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit of measurement is a standardized quantity of a physical quality.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uo.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000000</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000186 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000186">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000000"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of physical quantity consisting of only a numerical number without any units.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uo.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000186</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dimensionless unit</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000187 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000187">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000190"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A dimensionless ratio unit which denotes numbers as fractions of 100.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uo.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">%</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000187</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">percent</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000190 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000190">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000186"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A dimensionless unit which denotes an amount or magnitude of one quantity relative to another.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/uo.owl</obo:IAO_0000412>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000190</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 xml:lang="en">An information content entity that specifies how a dose is quantified in a dose administration.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/PDRO/PDRO.owl</obo:IAO_0000412>
<obo:IAO_0000600 xml:lang="en">This part of a prescription usually specifies a fixed amount (like '50 mg' or '500 mL'), but may instead specify a rate in some situations, e.g., in ongiong IV perfusions, where the total dose that will be administered in a single dose is unkown until the administration has ended. In either situation, the dose quantification specification is what enables the calculation of the quantity of active ingredient or drug product in the dose that is administered</obo:IAO_0000600>
<rdfs:label>dose quantification specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000124 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000124">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 xml:lang="en">A dose quantification specification that quantifies a dose by referring to the quantity of active ingredient administered in a dose administration.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/PDRO/PDRO.owl</obo:IAO_0000412>
<rdfs:label>active ingredient quantification specification</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000125 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000125">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
<obo:IAO_0000115 xml:lang="en">A dose quantification specification that quantifies a dose by referring to the quantity of drug product administered in a dose administration.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/PDRO/PDRO.owl</obo:IAO_0000412>
<rdfs:label>drug product quantification specification</rdfs:label>
</owl:Class>
<!-- http://www.ebi.ac.uk/efo/EFO_0000750 -->
<owl:Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000750">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://www.ebi.ac.uk/efo/efo.owl</obo:IAO_0000412>
<efo:ArrayExpress_label>Genotyping</efo:ArrayExpress_label>
<efo:NCI_Thesaurus_definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NCIt:C45447</efo:NCI_Thesaurus_definition_citation>
<efo:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An assay in which variation in the genome is analysed</efo:definition>
<efo:definition_citation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ArrayExpress production team</efo:definition_citation>
<efo:definition_editor rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James Malone</efo:definition_editor>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">genotyping</rdfs:label>
</owl:Class>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Individuals
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/OBI_0302900 -->
<owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/OBI_0302900">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/OBI_0302900"/>
</owl:NamedIndividual>
<rdf:Description>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</rdfs:comment>
</rdf:Description>
<rdf:Description>
<owl:deprecated></owl:deprecated>
</rdf:Description>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotations
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0302900">
<obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adapted from wikipedia [http://en.wikipedia.org/wiki/Randomization]</obo:IAO_0000119>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000412 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/obi.owl</obo:IAO_0000412>
<obo:IAO_0000111 xml:lang="en">group randomization</obo:IAO_0000111>
<rdfs:label xml:lang="en">group randomization</rdfs:label>
<obo:IAO_0000112 xml:lang="en">PMID: 18349405. Randomization reveals unexpected acute leukemias in Southwest Oncology Group prostate cancer trial. J Clin Oncol. 2008 Mar 20;26(9):1532-6.</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">A group assignment which relies on chance to assign materials to a group of materials in order to avoid bias in experimental set up.</obo:IAO_0000115>
<obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philippe Rocca-Serra</obo:IAO_0000117>
</rdf:Description>
</rdf:RDF>
<!-- Generated by the OWL API (version 4.5.9.2019-02-01T07:24:44Z) https://github.com/owlcs/owlapi -->
