targets, factors
ANG1, ANG1
ANG2, (!KLF2) & (HIF1 | AP1 |  ETS | FOXO1)
TIE1, (Integrin | ANG1 | ANG2) 
TIE2, TIE1 & ANG1 & (!ANG2) & ((!VEPTP) | KLF2 | ETS)
ShearStress, ShearStress 
VEPTP, HIF2a
mir126, KLF2
SPRED1, !mir126
PI3KR2, !mir126
NF1, SPRED1
KLF2, ShearStress
PIEZO1, ShearStress
TRPV4, ShearStress & !cGMP
Integrin, (ShearStress | TIE2) & ETS
GqG11, ShearStress
Actin, ShearStress
VEcadherin, ETS & (SRC | FAK | Actin | VEPTP)
PECAM1, FYN | Actin | VEcadherin
SHP2, PECAM1
FAK, SRC | Integrin
SRC, FAK | TSAd | GqG11
PI3K, AXL | (!PI3KR2) | VEcadherin | TIE2
AKT, PIP3
TSC, AMPK & (!AKT)
AXL, SRC
PIP3, PI3K & (!PTEN)
RHEB2, !TSC
FYN, TSAd
TSAd, VEGFR22 | VEGFR23
PTEN, CSL | RHO
BMP9, BMP9
BMP10, BMP10
TGFB1, TGFB1
ACVR2A, 1
BMPRII, 1
TGFBRII, 1
ALK1, (TGFB1 | BMP9 | BMP10) & (ACVR2A | BMPRII | TGFBRII)
ENG, TGFB1|BMP9|BMP10
ALK5, BMP9 & TGFBRII
BG, BMP9
SMAD4, 1
SMAD6, CSL
SMAD1, (!SMAD6) & (!NRP1) & ALK1 & ENG & SMAD4 
SMAD2, (!SMAD6) & (!NRP1) & ALK5 & BG & SMAD4
PDGFB, FOXO1 | SMAD2
TRAF6, ALK1
TAK1, TRAF6
sGC, 1
cGMP, NO & sGC
eNOS, AKT | SIRT1
NO, eNOS | Calmodulin
Calcium, IP3 | TRPV4 | PIEZO1 
Calmodulin, Calcium
Calcineurin, Calmodulin
NFAT, Calcineurin
ETS, ERK
RAS, SHP2 | ALK1 | (!NF1)
RAF1, (PKCB2 | RAS) & (!AKT)
MEK, RAF1 | FRS2a
ERK, MEK | VEGFR33
PLCg, VEGFR22 | VEGFR33 | DSH | FZD4_5
IP3, PLCg
DAG, PLCg
PKCB2, DAG & Calcium
AMPATP, AMPATP
AMPK, (AMPATP | (!Oxygen)) & (!AKT) 
mTOR, AMPK | RHEB2
HIF1, mTOR & !PHDs & SIRT1
FOXO1, SIRT1 & (!AKT)
ART1, (!NAD)
NAD, AMPK 
Oxygen, Oxygen
Lactate,!Oxygen
PHDs, Oxygen & !Lactate
HIF2a, SIRT1 | (!Oxygen)
LSD1, SIRT1 & (!NICD)
SIRT1, (HIF2a | HIF1 | FOXO1) & NAD
WNT5a, WNT5a
ROR, WNT5a
JNK, (ROR | RAC1) & DSH
AP1, JNK
FZD4_5, WNT5a
WNT11, WNT11
FZD6, WNT11 | WNT5a
RAC1, FZD6 & DSH
DAAM1, FZD6 | DSH
CDC42, DAAM1 
RHO, DAAM1 | NRP1
WNT7a, WNT7a & (!sFRP1)
sFRP1, 0
FZD4_7, WNT7a
LRP5_6, WNT7a & (!DKK1)
DKK1, 0
DSH, (FZD4_5 & ROR) | FZD6 | (FZD4_7 & LRP5_6)
GSK3B, !DSH & !LRP5_6
Axin2, LEF1
BTrCP, 0
Bcatenin, !GSK3B & !BTrCP
GROUCHO, !Bcatenin
LEF1, (Bcatenin & !GROUCHO) & (NRARP | LEF1)
CyclinD1, Bcatenin & LEF1
FGF, FGF
FGFR2, FGF
FRS2a, FGFR2
JAGa, SMAD1 | Bcatenin
JAGp, JAGp
DLL4a, ETS | CSL
DLL4p, DLL4p
ADAM10, 1
gSecretase, 1
Notch4, ETS
NOTCH, Notch4 & gSecretase & ADAM10 & DLL4p & (!JAGp)
NICD, NOTCH & (!NRARP)
CSL, NICD
NRARP, CSL
HEY1, CSL | ((SMAD1 | SMAD2) & (!SIRT1 & !LSD1))
Vegfr2, (ETS  & !HEY1) | Lactate
Vegfr1, CSL | ((HIF1 | ETS) & (!NFAT))
PlGF, PlGF
VEGFR1s, PlGF & Vegfr1
VEGFB, VEGFB
VEGFR11, Vegfr1 # (VEGFB | PlGF) activate it but for its main function, sequestering VEGFA
VEGFR12, Vegfr1 & Vegfr2 
IGF, IGF
PKC, IGF
ASF_SF2, PKC
VEGFAxxxP, VEGFAxxxP
VEGFAxxx, ((!(VEGFR1s | VEGFR12 | VEGFR11)) & VegfA & ART1 & ASF_SF2) | VEGFAxxxP
p38MAPK, TAK1 | SRC | DAG
CLK1, p38MAPK
CLK4, p38MAPK
SRP55, CLK4 | CLK1 
VEGFAxxxd, VegfA & SRP55
VEGFC_Dp, VEGFC_Dp
VEGFC_D, VEGFC_D
VEGFR22, Vegfr2 & (PECAM1 | ((VEGFC_Dp | VEGFAxxx) & !(VEGFAxxxd | VEPTP)))
Vegfr3, CSL
VEGFR23, Vegfr2 & Vegfr3 & (PECAM1 | VEGFAxxx | VEGFC_Dp)
VEGFR33, Vegfr3 & (PECAM1 | VEGFC_Dp | VEGFC_D)
STAT3, VEGFR22
VegfA, STAT3 | NFAT | HIF1 | Lactate | FOXO1 | KLF2
NRP1, (VEGFAxxx | VEGFC_Dp) & (!CSL | ETS)