Revision cd33a697a039ab75a1ddd3cb0689229d673ebf43 authored by andrewjpage on 26 June 2015, 13:40:24 UTC, committed by andrewjpage on 26 June 2015, 13:40:24 UTC
1 parent 4e8ae80
check_snp_searching.c
#include <stdio.h>
#include <stdlib.h>
#include <string.h>
#include <check.h>
#include "check_snp_searching.h"
#include "helper_methods.h"
#include "snp_searching.h"
START_TEST (check_find_starting_index_windows)
{
int coords_empty[0] = {};
int coords_one[1] = {1};
int coords_odd[3] = {1,3,5};
int coords_even[4] = {1,3,5,7};
fail_unless( find_starting_index(0, coords_empty, 0, 0) == 0);
fail_unless( find_starting_index(0, coords_one, 0, 1) == 0);
fail_unless( find_starting_index(1, coords_one, 0, 1) == 0);
fail_unless( find_starting_index(1, coords_odd, 0, 3) == 0);
fail_unless( find_starting_index(3, coords_odd, 0, 3) == 1);
fail_unless( find_starting_index(5, coords_odd, 0, 3) == 2);
fail_unless( find_starting_index(0, coords_odd, 0, 3) == 0);
fail_unless( find_starting_index(2, coords_odd, 0, 3) == 0);
fail_unless( find_starting_index(4, coords_odd, 0, 3) == 1);
fail_unless( find_starting_index(1, coords_even, 0, 4) == 0);
fail_unless( find_starting_index(3, coords_even, 0, 4) == 1);
fail_unless( find_starting_index(5, coords_even, 0, 4) == 2);
fail_unless( find_starting_index(7, coords_even, 0, 4) == 3);
fail_unless( find_starting_index(9, coords_even, 0, 4) == 3);
fail_unless( find_starting_index(0, coords_even, 0, 4) == 0);
fail_unless( find_starting_index(2, coords_even, 0, 4) == 0);
fail_unless( find_starting_index(4, coords_even, 0, 4) == 1);
fail_unless( find_starting_index(6, coords_even, 0, 4) == 2);
fail_unless( find_starting_index(8, coords_even, 0, 4) == 3);
}
END_TEST
START_TEST (check_advance_window_start_to_next_snp)
{
int coords_empty[0] = {};
int coords_one[1] = {1};
int coords_odd[3] = {1,3,5};
int coords_even[4] = {1,3,5,7};
char *child_sequence_without_gaps = "ACGT";
char *child_sequence_with_gaps = "-AG-";
// Without gaps
fail_unless( advance_window_start_to_next_snp(0, coords_empty,child_sequence_without_gaps, 0) == 0);
fail_unless( advance_window_start_to_next_snp(0, coords_one, child_sequence_without_gaps, 1) == 1);
fail_unless( advance_window_start_to_next_snp(1, coords_one, child_sequence_without_gaps, 1) == 1);
fail_unless( advance_window_start_to_next_snp(1, coords_odd, child_sequence_without_gaps, 3) == 1);
fail_unless( advance_window_start_to_next_snp(3, coords_odd, child_sequence_without_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(5, coords_odd, child_sequence_without_gaps, 3) == 5);
fail_unless( advance_window_start_to_next_snp(0, coords_odd, child_sequence_without_gaps, 3) == 1);
fail_unless( advance_window_start_to_next_snp(2, coords_odd, child_sequence_without_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(4, coords_odd, child_sequence_without_gaps, 3) == 5);
fail_unless( advance_window_start_to_next_snp(1, coords_even, child_sequence_without_gaps, 4) == 1);
fail_unless( advance_window_start_to_next_snp(3, coords_even, child_sequence_without_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(5, coords_even, child_sequence_without_gaps, 4) == 5);
fail_unless( advance_window_start_to_next_snp(7, coords_even, child_sequence_without_gaps, 4) == 7);
fail_unless( advance_window_start_to_next_snp(9, coords_even, child_sequence_without_gaps, 4) == 9);
fail_unless( advance_window_start_to_next_snp(0, coords_even, child_sequence_without_gaps, 4) == 1);
fail_unless( advance_window_start_to_next_snp(2, coords_even, child_sequence_without_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(4, coords_even, child_sequence_without_gaps, 4) == 5);
fail_unless( advance_window_start_to_next_snp(6, coords_even, child_sequence_without_gaps, 4) == 7);
fail_unless( advance_window_start_to_next_snp(8, coords_even, child_sequence_without_gaps, 4) == 8);
// With gaps
fail_unless( advance_window_start_to_next_snp(0, coords_empty,child_sequence_with_gaps, 0) == 0);
fail_unless( advance_window_start_to_next_snp(0, coords_one, child_sequence_with_gaps, 1) == 1);
fail_unless( advance_window_start_to_next_snp(1, coords_one, child_sequence_with_gaps, 1) == 1);
fail_unless( advance_window_start_to_next_snp(1, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(3, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(5, coords_odd, child_sequence_with_gaps, 3) == 5);
fail_unless( advance_window_start_to_next_snp(0, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(2, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( advance_window_start_to_next_snp(4, coords_odd, child_sequence_with_gaps, 3) == 5);
fail_unless( advance_window_start_to_next_snp(1, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(3, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(5, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( advance_window_start_to_next_snp(7, coords_even, child_sequence_with_gaps, 4) == 7);
fail_unless( advance_window_start_to_next_snp(9, coords_even, child_sequence_with_gaps, 4) == 9);
fail_unless( advance_window_start_to_next_snp(0, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(2, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( advance_window_start_to_next_snp(4, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( advance_window_start_to_next_snp(6, coords_even, child_sequence_with_gaps, 4) == 7);
fail_unless( advance_window_start_to_next_snp(8, coords_even, child_sequence_with_gaps, 4) == 8);
}
END_TEST
START_TEST (check_rewind_window_end_to_last_snp)
{
int coords_empty[0] = {};
int coords_one[1] = {1};
int coords_odd[3] = {1,3,5};
int coords_even[4] = {1,3,5,7};
char *child_sequence_without_gaps = "ACGT";
char *child_sequence_with_gaps = "-AG-";
// Without gaps
fail_unless( rewind_window_end_to_last_snp(0, coords_empty,child_sequence_without_gaps, 0) == 0);
fail_unless( rewind_window_end_to_last_snp(0, coords_one, child_sequence_without_gaps, 1) == 0);
fail_unless( rewind_window_end_to_last_snp(1, coords_one, child_sequence_without_gaps, 1) == 1);
fail_unless( rewind_window_end_to_last_snp(1, coords_odd, child_sequence_without_gaps, 3) == 1);
fail_unless( rewind_window_end_to_last_snp(3, coords_odd, child_sequence_without_gaps, 3) == 3);
fail_unless( rewind_window_end_to_last_snp(5, coords_odd, child_sequence_without_gaps, 3) == 5);
fail_unless( rewind_window_end_to_last_snp(0, coords_odd, child_sequence_without_gaps, 3) == 0);
fail_unless( rewind_window_end_to_last_snp(2, coords_odd, child_sequence_without_gaps, 3) == 1);
fail_unless( rewind_window_end_to_last_snp(4, coords_odd, child_sequence_without_gaps, 3) == 3);
fail_unless( rewind_window_end_to_last_snp(1, coords_even, child_sequence_without_gaps, 4) == 1);
fail_unless( rewind_window_end_to_last_snp(3, coords_even, child_sequence_without_gaps, 4) == 3);
fail_unless( rewind_window_end_to_last_snp(5, coords_even, child_sequence_without_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(7, coords_even, child_sequence_without_gaps, 4) == 7);
fail_unless( rewind_window_end_to_last_snp(9, coords_even, child_sequence_without_gaps, 4) == 7);
fail_unless( rewind_window_end_to_last_snp(0, coords_even, child_sequence_without_gaps, 4) == 0);
fail_unless( rewind_window_end_to_last_snp(2, coords_even, child_sequence_without_gaps, 4) == 1);
fail_unless( rewind_window_end_to_last_snp(4, coords_even, child_sequence_without_gaps, 4) == 3);
fail_unless( rewind_window_end_to_last_snp(6, coords_even, child_sequence_without_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(8, coords_even, child_sequence_without_gaps, 4) == 7);
fail_unless( rewind_window_end_to_last_snp(0, coords_empty,child_sequence_with_gaps, 0) == 0);
fail_unless( rewind_window_end_to_last_snp(0, coords_one, child_sequence_with_gaps, 1) == 0);
fail_unless( rewind_window_end_to_last_snp(1, coords_one, child_sequence_with_gaps, 1) == 1);
fail_unless( rewind_window_end_to_last_snp(1, coords_odd, child_sequence_with_gaps, 3) == 1);
fail_unless( rewind_window_end_to_last_snp(3, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( rewind_window_end_to_last_snp(5, coords_odd, child_sequence_with_gaps, 3) == 5);
fail_unless( rewind_window_end_to_last_snp(0, coords_odd, child_sequence_with_gaps, 3) == 0);
fail_unless( rewind_window_end_to_last_snp(2, coords_odd, child_sequence_with_gaps, 3) == 2);
fail_unless( rewind_window_end_to_last_snp(4, coords_odd, child_sequence_with_gaps, 3) == 3);
fail_unless( rewind_window_end_to_last_snp(1, coords_even, child_sequence_with_gaps, 4) == 1);
fail_unless( rewind_window_end_to_last_snp(3, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( rewind_window_end_to_last_snp(5, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(7, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(9, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(0, coords_even, child_sequence_with_gaps, 4) == 0);
fail_unless( rewind_window_end_to_last_snp(2, coords_even, child_sequence_with_gaps, 4) == 2);
fail_unless( rewind_window_end_to_last_snp(4, coords_even, child_sequence_with_gaps, 4) == 3);
fail_unless( rewind_window_end_to_last_snp(6, coords_even, child_sequence_with_gaps, 4) == 5);
fail_unless( rewind_window_end_to_last_snp(8, coords_even, child_sequence_with_gaps, 4) == 5);
}
END_TEST
START_TEST (check_get_window_end_coordinates_excluding_gaps)
{
int coords_empty[0] = {};
int coords_one[1] = {1};
int coords_odd[3] = {1,3,5};
int coords_even[8] = {1,3,5,7,11,13,17,19};
char *child_sequence_without_gaps = "ACGTACGT";
char *child_sequence_with_gaps = "-AC-GT-A";
//int get_window_end_coordinates_excluding_gaps(1, 3, coords_even, char * child_sequence, int number_of_snps)
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_empty,child_sequence_without_gaps, 0) == 3);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_one, child_sequence_without_gaps, 1) == 3);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_one, child_sequence_without_gaps, 1) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_odd, child_sequence_without_gaps, 3) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(3, 3, coords_odd, child_sequence_without_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(5, 3, coords_odd, child_sequence_without_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_odd, child_sequence_without_gaps, 3) == 3);
fail_unless( get_window_end_coordinates_excluding_gaps(2, 3, coords_odd, child_sequence_without_gaps, 3) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(4, 3, coords_odd, child_sequence_without_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_even, child_sequence_without_gaps, 8) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(3, 3, coords_even, child_sequence_without_gaps, 8) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(5, 3, coords_even, child_sequence_without_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(7, 3, coords_even, child_sequence_without_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(9, 3, coords_even, child_sequence_without_gaps, 8) == 12);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_even, child_sequence_without_gaps, 8) == 3);
fail_unless( get_window_end_coordinates_excluding_gaps(2, 3, coords_even, child_sequence_without_gaps, 8) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(4, 3, coords_even, child_sequence_without_gaps, 8) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(6, 3, coords_even, child_sequence_without_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(8, 3, coords_even, child_sequence_without_gaps, 8) == 11);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_empty,child_sequence_with_gaps, 0) == 3);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_one, child_sequence_with_gaps, 1) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_one, child_sequence_with_gaps, 1) == 5);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_odd, child_sequence_with_gaps, 3) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(3, 3, coords_odd, child_sequence_with_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(5, 3, coords_odd, child_sequence_with_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_odd, child_sequence_with_gaps, 3) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(2, 3, coords_odd, child_sequence_with_gaps, 3) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(4, 3, coords_odd, child_sequence_with_gaps, 3) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(1, 3, coords_even, child_sequence_with_gaps, 8) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(3, 3, coords_even, child_sequence_with_gaps, 8) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(5, 3, coords_even, child_sequence_with_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(7, 3, coords_even, child_sequence_with_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(9, 3, coords_even, child_sequence_with_gaps, 8) == 12);
fail_unless( get_window_end_coordinates_excluding_gaps(0, 3, coords_even, child_sequence_with_gaps, 8) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(2, 3, coords_even, child_sequence_with_gaps, 8) == 4);
fail_unless( get_window_end_coordinates_excluding_gaps(4, 3, coords_even, child_sequence_with_gaps, 8) == 6);
fail_unless( get_window_end_coordinates_excluding_gaps(6, 3, coords_even, child_sequence_with_gaps, 8) == 8);
fail_unless( get_window_end_coordinates_excluding_gaps(8, 3, coords_even, child_sequence_with_gaps, 8) == 11);
}
END_TEST
START_TEST (check_find_number_of_snps_in_block)
{
int coords_empty[0] = {};
int coords_even[8] = {1,3,5,7,11,13,17,19};
char *child_sequence = "AAAAA-AAAAAAAAAAAAA";
fail_unless( find_number_of_snps_in_block(1,3, coords_empty, child_sequence, 0) == 0);
fail_unless( find_number_of_snps_in_block(2,2, coords_even, child_sequence, 8) == 0);
fail_unless( find_number_of_snps_in_block(1,3, coords_even, child_sequence, 8) == 1);
fail_unless( find_number_of_snps_in_block(1,4, coords_even, child_sequence, 8) == 2);
fail_unless( find_number_of_snps_in_block(1,5, coords_even, child_sequence, 8) == 2);
fail_unless( find_number_of_snps_in_block(1,19, coords_even, child_sequence, 8) == 7);
fail_unless( find_number_of_snps_in_block(0,20, coords_even, child_sequence, 8) == 8);
}
END_TEST
//int calculate_number_of_snps_excluding_gaps(char * ancestor_sequence, char * child_sequence, int child_sequence_size, int * branch_snp_coords, int * snp_locations)
START_TEST (check_calculate_number_of_snps_excluding_gaps)
{
char * ancestor_sequence_no_snps = "AAAAAAAAAA";
char * ancestor_sequence_one_snp = "AAAAA.AAAA";
char * ancestor_sequence_many_snps = "TAAATAAATT";
char * ancestor_sequence_gaps = "TAAATTAAAT";
char * child_sequence_no_snps = "AAAAAAAAAA";
char * child_sequence_one_snp = "AAAAACAAAA";
char * child_sequence_many_snps = "CAAACAAACC";
char * child_sequence_gaps = "-AAAC----C";
char * child_ancestor_sequence = "AAAACAAAAC";
char * ancestor_sequence_with_dots = "ACAACAAAAC";
int child_sequence_size = 10;
int * branch_snp_coords;
char * branch_snp_sequence ;
char * branch_ancestor_snp_sequence ;
int snp_locations[10] = {0,4,8,20,30,40,50,88,90,100};
branch_snp_coords = (int *) malloc((child_sequence_size+1)*sizeof(int));
branch_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
branch_ancestor_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
fail_unless( calculate_number_of_snps_excluding_gaps(ancestor_sequence_no_snps, child_sequence_no_snps, child_sequence_size, branch_snp_coords, snp_locations,branch_snp_sequence,branch_ancestor_snp_sequence ) == 0 );
fail_unless(strcmp(branch_snp_sequence, "") == 0);
fail_unless(strcmp(branch_ancestor_snp_sequence, "") == 0);
branch_snp_coords = (int *) malloc((child_sequence_size+1)*sizeof(int));
branch_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
branch_ancestor_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
fail_unless( calculate_number_of_snps_excluding_gaps(ancestor_sequence_one_snp, child_sequence_one_snp, child_sequence_size, branch_snp_coords, snp_locations,branch_snp_sequence,branch_ancestor_snp_sequence ) == 1 );
fail_unless(strcmp(branch_snp_sequence, "C") == 0);
fail_unless(strcmp(branch_ancestor_snp_sequence, ".") == 0);
fail_unless(branch_snp_coords[0] == 40);
branch_snp_coords = (int *) malloc((child_sequence_size+1)*sizeof(int));
branch_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
branch_ancestor_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
fail_unless( calculate_number_of_snps_excluding_gaps(ancestor_sequence_many_snps, child_sequence_many_snps, child_sequence_size, branch_snp_coords, snp_locations,branch_snp_sequence,branch_ancestor_snp_sequence ) == 4 );
fail_unless(strcmp(branch_snp_sequence, "CCCC") == 0);
fail_unless(strcmp(branch_ancestor_snp_sequence, "TTTT") == 0);
fail_unless(branch_snp_coords[0] == 0);
fail_unless(branch_snp_coords[3] == 100);
branch_snp_coords = (int *) malloc((child_sequence_size+1)*sizeof(int));
branch_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
branch_ancestor_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
fail_unless( calculate_number_of_snps_excluding_gaps(ancestor_sequence_gaps, child_sequence_gaps, child_sequence_size, branch_snp_coords, snp_locations,branch_snp_sequence,branch_ancestor_snp_sequence ) == 2 );
fail_unless(strcmp(branch_snp_sequence, "CC") == 0);
fail_unless(strcmp(branch_ancestor_snp_sequence, "TT") == 0);
fail_unless(branch_snp_coords[0] == 30);
fail_unless(branch_snp_coords[1] == 100);
branch_snp_coords = (int *) malloc((child_sequence_size+1)*sizeof(int));
branch_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
branch_ancestor_snp_sequence = (char *) malloc((child_sequence_size+1)*sizeof(char));
fail_unless( calculate_number_of_snps_excluding_gaps(ancestor_sequence_with_dots, child_ancestor_sequence, child_sequence_size, branch_snp_coords, snp_locations,branch_snp_sequence,branch_ancestor_snp_sequence ) == 1);
fail_unless(strcmp(branch_snp_sequence, "A") == 0);
fail_unless(strcmp(branch_ancestor_snp_sequence, "C") == 0);
fail_unless(branch_snp_coords[0] == 4);
}
END_TEST
Suite * check_snp_searching_suite (void)
{
Suite *s = suite_create ("snp_searching");
TCase *tc_snp_searching = tcase_create ("snp_searching");
tcase_add_test (tc_snp_searching, check_find_starting_index_windows );
tcase_add_test (tc_snp_searching, check_advance_window_start_to_next_snp);
tcase_add_test (tc_snp_searching, check_rewind_window_end_to_last_snp);
tcase_add_test (tc_snp_searching, check_get_window_end_coordinates_excluding_gaps);
tcase_add_test (tc_snp_searching, check_find_number_of_snps_in_block);
tcase_add_test (tc_snp_searching, check_calculate_number_of_snps_excluding_gaps);
suite_add_tcase (s, tc_snp_searching);
return s;
}
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