swh:1:snp:ff0951ca787d0b7f47dc2335f47fed43820a6324
Tip revision: 4b519f6c36e35e4b0c9d2e052a1710b5a42e0eda authored by Venkatraman E. Seshan on 13 September 2011, 00:00:00 UTC
version 0.9.8
version 0.9.8
Tip revision: 4b519f6
fedesign.Rd
\name{fedesign}
\title{Trial Designs Based On Fisher's Exact Test}
\alias{fedesign}
\alias{fe.ssize}
\alias{CPS.ssize}
\alias{fe.mdor}
\alias{fe.power}
\alias{or2pcase}
\keyword{design}
\description{Calculates sample size, effect size and power based on
Fisher's exact test}
\usage{
fe.ssize(p1,p2,alpha=0.05,power=0.8,r=1,npm=5,mmax=1000)
CPS.ssize(p1,p2,alpha=0.05,power=0.8,r=1)
fe.mdor(ncase,ncontrol,pcontrol,alpha=0.05,power=0.8)
fe.power(d, n1, n2, p1, alpha = 0.05)
or2pcase(pcontrol, OR)
}
\arguments{
\item{p1}{response rate of standard treatment}
\item{p2}{response rate of experimental treatment}
\item{d}{difference = p2-p1}
\item{pcontrol}{control group probability}
\item{n1}{sample size for the standard treatment group}
\item{n2}{sample size for the standard treatment group}
\item{ncontrol}{control group sample size}
\item{ncase}{case group sample size}
\item{alpha}{size of the test (default 5\%)}
\item{power}{power of the test (default 80\%)}
\item{r}{treatments are randomized in 1:r ratio (default r=1)}
\item{npm}{the sample size program searches for sample sizes in a
range (+/- npm) to get the exact power}
\item{mmax}{the maximum group size for which exact power is
calculated}
\item{OR}{odds-ratio}
}
\details{
CPS.ssize returns Casagrande, Pike, Smith sample size which is a very
close to the exact. Use this for small differences p2-p1 (hence large
sample sizes) to get the result instantaneously.
fe.ssize return a 2x3 matrix with CPS and Fisher's exact sample sizes
with power.
fe.mdor return a 3x2 matrix with Schlesselman, CPS and Fisher's exact
minimum detectable odds ratios and the corresponding power.
fe.power returns a Kx2 matrix with probabilities (p2) and exact power.
or2pcase give the probability of disease among the cases for a given
probability of disease in controls (pcontrol) and odds-ratio (OR).
}
\references{
Casagrande, JT., Pike, MC. and Smith PG. (1978). An improved
approximate formula for calculating sample sizes for comparing two
binomial distributions. \emph{Biometrics} 34, 483-486.
Fleiss, J. (1981) Statistical Methods for Rates and Proportions.
Schlesselman, J. (1987) Re: Smallest Detectable Relative Risk With
Multiple Controls Per Case. \emph{Am. J. Epi.}
}